Browsing Molecular Biophysics Unit (MBU) by Subject "Deep mutational scanning"
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Deep Mutational Scanning Analyses of Protein Stability and Function
Full text Embargo up to Sep 2026 Protein stability is critical to understanding protein function, folding, and interactions within living organisms. It plays a key role in protein engineering, where designing stable ... -
Deep mutational scanning to enhance immunogenicity and map antibody responses to HIV-1
Vaccines have proven effective against numerous viral diseases, yet the development of a successful vaccine for Human Immunodeficiency Virus (HIV-1) remains elusive. A key immunogen for vaccine design is the surface ... -
Design of viral entry inhibitors and vaccines
Full text Embargo upto 12/12/2026 Human Immunodeficiency Virus type 1 (HIV-1) remains one of the most persistent global health threats, despite significant efforts in the development of vaccines and major strides in ... -
Determinants of protein stability and function inferred from saturation mutagenesis and next-generation sequencing
Proteins play a central role in all biological processes. Despite a similar underlying composition, they exhibit immense diversity in structures and functions, a subject of great interest. The research presented in this ...