Browsing Molecular Biophysics Unit (MBU) by thesis submitted date"2010"
Now showing items 1-13 of 13
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Conformational Analysis And Design Of Disulfides In Antiparallel β-Sheets And Helices
(2013-08-30)Disulfides are the primary covalent interactions within a protein molecule that connect residues which are sequentially distant. Naturally occurring disulfides enhance the stability of the protein by destabilization of ... -
Development And Applications Of Computational Methods To Aid Recognition Of Protein Functions And Interactions
(2011-10-03)Protein homology detection has played a central role in the understanding of evolution of protein structures, functions and interactions. Many of the developments in protein bioinformatics can be traced back to an initial ... -
Intrinsic Versus Induced Variations In DNA Structure
(2011-07-18)The binding of different proteins involved in processes such as transcription, replication and chromatin compaction to regions of the genome is regulated by the structure of DNA. Thus, DNA structure acts as the crucial ... -
Mechanistic And Regulatory Aspects Of The Mycobacterium Tuberculosis Dephosphocoenzyme A Kinase
(2013-09-11)The current, grim world-TB scenario, with TB being the single largest infectious disease killer, warrants a more effective approach to tackle the deadly pathogen, Mycobacterium tuberculosis. The deadly synergy of this ... -
Role of an RNA Polymerase Interacting Protein, MsRbpA, from Mycobacterium smegmatis in Phenotypic Tolerance to Rifampicin
Rifampicin is a non-competitive inhibitor of bacterial RNA polymerase (RNAP). The knowledge about the mechanism of action of this drug has emanated from the genetic and the biochemical studies carried out on Escherichia ... -
Structural And Functional Studies On Staphylococcus Aureus Enzymes Involved In L-Lysine Biosynthesis
(2011-05-24)Proteins associated with metabolic pathways have received considerable attention in an effort to understand the molecular details of the complex reactions catalyzed in vivo. Enzymes belonging to these pathways have also ... -
Structural Studies Of Mycobacterial Uracil-DNA Glycosylase (Ung) And Single-Stranded DNA Binding Protein (SSB)
(2011-09-21)For survival and successful propagation, every organism has to maintain the genomic integrity of the cell. The information content, in the form of nucleotide bases, is constantly threatened by endogenous agents and ... -
Structural Studies On Mycobacterium Tuberculosis Pantothenate Kinase (PanK)
(2011-07-18)Pantothenate kinase (PanK) is an ubiquitous and essential enzyme that catalyzes the first step in the universal Coenzyme (CoA) biosynthesis pathway. In this step, pantothenate (Vitamin B5) is converted to 4′-phosphopantothenate, ... -
Structural Studies On The Rotaviral Enterotoxin NSP4
(2013-02-12) -
Structural Studies On Three-Fold Symmetric Plant Lectins
(2013-05-21)Lectins, multivalent carbohydrate-binding proteins of non-immune origin, have the unique ability to decode the information contained in complex carbohydrate structures of glycoproteins and glycolipids by stereo-specifically ... -
Structural, Biophysical And Biochemical Studies On Mannose-Specific Lectins
(2013-01-17)For a long time, the scientific community underestimated the value of carbohydrates and the approach of most scientists to the complex world of glycans was apprehensive. The scenario, however, has changed today. With the ... -
Structure Analysis Of FabI And FabZ Enzymes Of The Fatty Acid Biosynthesis Pathway Of Plasmodium Falciparum
(2013-08-30)The emergence of drug resistant strains of Plasmodium has given a new face to the old disease, malaria. One of the approaches is to block metabolic pathways of the pathogen. The current thesis describes the X-ray ... -
Topology-based Sequence Design For Proteins Structures And Statistical Potentials Sensitive To Local Environments
(2013-01-17)Proteins, which regulate most of the biological activities, perform their functions through their unique three-dimensional structures. The folding process of this three dimensional structure from one dimensional sequence ...