Browsing Molecular Biophysics Unit (MBU) by thesis submitted date"1994"
Now showing items 1-6 of 6
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Characterization of ligand binding in ribonuclease a computer modelling and simulation approach
In recent times, the fields of biochemistry, molecular biology, structural studies, and biomolecular computation have moved closer to each other and are now interconnected. Often, the inputs from one discipline can serve ... -
Conformational search of cyclic ionophores & characterization of proline helices with constraints by molecular dynamics studies
It has been found that valinomycin assumes a variety of conformations depending on the environment. Its ability to selectively complex with K ions and transport them through the membrane is related to its ability to adopt ... -
Model building and molecular mechanics studies on G-Tetraplex and B-Z-B DNA motifs
For almost 25 years following the proposal of the doublehelix structure by Watson and Crick, this model was believed to be the only structure for DNA. Even though various polymorphic forms such as A, B, C, and D were ... -
Non Protein amino acids in De Novo design : an evaluation
The studies described in this chapter have focused on conformational analysis of two antigenic sequences from the N- and C-termini of the chicken riboflavin carrier protein (cRCP). Both sequences investigated have a length ... -
Repetitive sequences, unusual DNA structures and chromatin organisation
Since the discovery of DNA and the proposal of the double helix structure, we have come a long way in understanding the molecular basis of heredity. With the ability to synthesize any DNA sequence of interest and improved ... -
Studies on novel structural motifs using synthetic oligodeoxyribonucleotides
The double helical structure of DNA proposed by Watson and Crick was once thought to be rigid and monotonous in structural terms. Although the inherent conformational flexibility in DNA was envisioned through theoretical ...