Browsing Molecular Biophysics Unit (MBU) by Title
Now showing items 362-380 of 380
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Understanding Bacterial Heterogeneity in Gene Expression Under Specific and Global Regulatory Control
Intrinsic heterogeneity in natural bacterial populations enable them to escape sudden changes in environment and evolve. Processes like cellular crosstalk, abiotic interactors, host interactions, intracellular signalling ... -
Understanding intramolecular signal transduction in regulated proteases of the High Temperature Requirement A family
Protein homeostasis in all organisms is a complex process involving regulatory mechanisms that govern protein synthesis, post-translational events and degradation. The protein degradation mechanism serves multiple functions ... -
Understanding protein structural excursions using residue networks and implications on biological function
The information required for a protein structure to fold into the native conformation is encoded in its sequence. Studying protein structures help to understand their biological function. Molecular interactions between ... -
Understanding structure, function, and dynamics in macromolecular complexes
In the scope of my thesis work, a concerted effort was undertaken to elucidate bi- ological functions through the lens of structural analysis, employing protein dy- namics. The role of protein dynamics in shaping and ... -
Understanding the interaction mechanism of bacterial virulence factors and effector proteins with host lipid membrane using single particle cryo-electron microscopy
Pathogenic bacteria employ an array of biological macromolecules and cellular structures that help in the initiation and progression of disease in host organism. These ‘virulence factors’ can either be secreted by the ... -
Understanding the Regulatory Steps that Govern the Activation of Mycobacterium Tuberculosis σK
(2018-07-28)A distinctive feature of host-pathogen interactions in the case of Mycobacterium tuberculosis is the asymptomatic latent phase of infection. The ability of the bacillus to survive for extended periods of time in the host ... -
Understanding the role of arginine clusters in β-hairpin antimicrobial peptides
The work described in this thesis describes the role of arginine clusters and the importance of their position in B-hairpin antimicrobial peptides. Here, we have tried to explore the role of guanidinium groups in the ... -
Unusual Acylation Properties Of Type II Fatty Acid Biosynthesis Acyl Carrier Proteins
(2010-07-06)This thesis entitled ‘ Unusual Acylation Properties of Type II Fatty Acid Biosynthesis Acyl Carrier Proteins’ describes the discovery of self-acylation and malonyl transferase activity in acyl carrier proteins involved in ... -
Use of strategically designed protein-like sequences in structure and function recognition
The advent of high fidelity protein sequencing techniques has led to a considerable wealth of sequence data. However, the number of proteins with information on 3-D structure and functional features available is considerably ... -
Use of sub-family specific residues of protein modules in recognizing sites of functional and structural specialization
Functional and regulatory features of a protein in a living system are determined by several factors such as chemical nature and three-dimensional arrangement of residues in the functional site, spatial and temporal ... -
X-ray crystallagraphic studies on the effect of chirality in amino acids aggregation
A programme of systematic X-ray studies on crystalline complexes involving amino acids and peptides is currently under way in this laboratory. These studies, apart from providing a wealth of information on non-covalent ... -
X-ray crystallographic studies of amino acid-carboxylic acid complexes
The structure, assembly and action of proteins critically depend upon non?covalent interactions. A programme aimed at elucidating the atomic details of such interactions using an approach involving the preparation and X?ray ... -
X-ray Crystallographic studies on some helical peptides containing alpha-aminoisobutyric acid
Abstract not available -
X-ray crystallographic studies on the structure and interactions of L-ascorbic acids
It is well known that non?covalent interactions endow biological systems with extreme subtlety and complexity. In fact, the structure and assembly of proteins, and the dynamical processes involved in their action, are ... -
X-RAY CRYSTALLOGRAPHY OF SOME ANALGETIC PYRAZOLE DERIVATIVES AND FENAMATES
This thesis reports the crystal structure investigations carried out by the author on five non-steroidal anti-inflammatory, antipyretic analgesic drugs as part of an ongoing programme in this laboratory. Two of these drugs ... -
X-ray differaction studies on belladonna mottle virus at 3.8 A resolution
Tymoviruses are a group of highly infectious plant viruses found in several geographical locations. The type member of this group of viruses, turnip yellow mosaic virus, has been studied in detail regarding its architecture, ... -
X-ray diffraction and theoretical studies on DNA and ligand-DNA interaction.
Abstract not available -
X-ray studies on some proline containing peptides
The imino acid proline plays a crucial role in determining the conformation of proteins, peptides, and peptide antibiotics. Understanding the intrinsic propensities of prolyl residues to assume different characteristic ...