Browsing Molecular Biophysics Unit (MBU) by Title
Now showing items 375-394 of 411
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Targeting The CD4 Biniding Site In HIV-1 Immunogen Design
(2016-11-15)Over three decades have passed since the discovery of HIV-1, yet an AIDS vaccine remains elusive. The envelope glycoprotein of HIV-1 gp120, is the most exposed protein on the viral surface and thus serves as an important ... -
Temporal patterns of neural activity governing spatial representation in the hippocampus
Space is a fundamental substrate for animal interactions with the external world. The hippocampus, a region deep within the temporal lobe of mammalian brains, is a multisensory structure that has been heavily implicated ... -
The Modes of binding of carbohydrates to concanavalin a : a computer modelling approach
Concanavalin A (Con A), the carbohydrate?binding protein (lectin) originally isolated from the jack bean (Canavalia ensiformis), specifically binds to carbohydrates containing ??D?mannose and ??D?glucose residues in ... -
Theoretical investigation on the geminal proton-carnon-13 Coupling constants
It has been concluded from the present study that the geminal proton coupling of carboxyl (carbonyl) carbon-13 has an angular dependence of the form: A+Bcos?2?A + B \cos^2 \thetaA+Bcos2? based on the relative orientation ... -
Theoretical studies on peptide conformation
It is now well established that the biological activities of polypeptides and proteins are intimately connected with their 3-dimensional structures and so the determinations of these provide insight into their mode of ... -
Theoretical studies on the conformation and mode of binding of some inhibitors of thermolysin
Abstract not available -
Theoretical studies on the influence of exo-anomeric effect,geometry of sugar linkage on the unperturbed dimensions of polysaccharides
Recently, application of conformational energy calculations in the field of carbohydrates has led to a number of interesting and important results. A few attempts have also been made to compute the unperturbed dimensions ... -
Theoretical, Spectroscopic and crystallographic studies on peptide stuctures
The results reported in this part of the thesis—namely those on formamide, N-methylformamide (including isotopically enriched species), and N-methylacetamide—show significant non?planar distortions around the nitrogen atom. ... -
Theoritical studies on the molecular structure of collagen and related polypeptides
In Section 1.5, it is seen that hydroxyproline residues can give added stability to the collagen fibers by forming both intra- as well as intermolecular hydrogen bonds involving the ?-hydroxyl group. 2.4 Conclusion It ... -
Thermodynamic Characterization Of Wild Type And Mutants Of The E.coli Periplasmic Binding Proteins LBP, LIVBP, MBP And RBP
(2009-03-13)Native states of globular proteins typically show stabilization in the range of 5 to 15 kcal/mol with respect to their unfolded states. There has been a considerable progress in the area of protein stability and folding ... -
Theta-band Spectral Selectivity and Gamma-range Coincidence Detection in Spike Initiation Dynamics of Hippocampal Pyramidal Neurons
In the pursuit to understand information processing in the brain, a general question that is often posed is: What is the neuron encoding? This is addressed by assessing feature selectivity in sensory neurons, which informs ... -
Topology-based Sequence Design For Proteins Structures And Statistical Potentials Sensitive To Local Environments
(2013-01-17)Proteins, which regulate most of the biological activities, perform their functions through their unique three-dimensional structures. The folding process of this three dimensional structure from one dimensional sequence ... -
Understanding Bacterial Heterogeneity in Gene Expression Under Specific and Global Regulatory Control
Intrinsic heterogeneity in natural bacterial populations enable them to escape sudden changes in environment and evolve. Processes like cellular crosstalk, abiotic interactors, host interactions, intracellular signalling ... -
Understanding intramolecular signal transduction in regulated proteases of the High Temperature Requirement A family
Protein homeostasis in all organisms is a complex process involving regulatory mechanisms that govern protein synthesis, post-translational events and degradation. The protein degradation mechanism serves multiple functions ... -
Understanding protein structural excursions using residue networks and implications on biological function
The information required for a protein structure to fold into the native conformation is encoded in its sequence. Studying protein structures help to understand their biological function. Molecular interactions between ... -
Understanding structure, function, and dynamics in macromolecular complexes
In the scope of my thesis work, a concerted effort was undertaken to elucidate bi- ological functions through the lens of structural analysis, employing protein dy- namics. The role of protein dynamics in shaping and ...