Browsing Molecular Biophysics Unit (MBU) by Title
Now showing items 81-100 of 332
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Endotoxin Peptide/Protein Interactions: Thermodynamic And Kinetic Analysis
(Indian Institute of Science, 2006-05-15)Endotoxin or Lipopolysaccharide (LPS) is the invariant structural component of gram negative bacterial outer membranes and is the chief causative factor of Sepsis or endotoxic shock. Sepsis is a syndrome that has very high ... -
Energetics Of Protein-Carbohydrate Recognition
(Indian Institute of Science, 2006-04-28)The work embodied in this thesis pertains to an attempt to understand better, the molecular basis of protein-carbohydrate recognition. For this purpose a systematic study was undertaken, not only of the energetics of ... -
Engineering Reverse Turns: Implications in Conformation, Stability and Bioactivity of Peptides and Proteins
The work presented in this thesis provides an overview of the potential role of N-methylation in inducing reverse turns. Backbone N-methylation is one of the common modifications designed by nature and exploited by humans ... -
Enhancing Therapeutic Potential of Antimicrobial Peptides by Tuning Backbone Conformation
Full text embargo up to Dec 31, 2026 The work reported in this thesis involves tuning the backbone conformation of b-hairpin AMPs to reduce their cytotoxicity, which is determined in terms of reduced hemolytic activity, ... -
Epileptiform Activity Induced Alterations In Ca2+ Dynamics And Network Physiology Of Hippocampal Neurons - In Vitro Studies
(2010-07-15)Epilepsy is characterized by the hyperexcitability of individual neurons and hyper synchronization of groups of neurons (networks). The acquired changes that take place at molecular, cellular and network levels are important ... -
Estradiol Induced Changes In Neuronal Excitability And Neuron-Astrocyte Signaling In Mixed Hippocampal Cultures
(2010-03-02)One of the defining characteristics of the brain is its plasticity, which is the ability to alter and reorganize neuronal circuits. The brain is constantly being shaped and moulded by the external world through endogenous ... -
Expanding The Horizon Of Mycobacterial Stress Response : Discovery Of A Second (P)PPGPP Synthetase In Mycobacterium Smegmatis
(2015-12-21)The stringent response is a highly conserved physiological response mounted by bacteria under stress (Ojha and Chatterji, 2001; Magnusson et al., 2005; Srivatsan and Wang, 2007; Potrykus and Cashel, 2008). Until recently, ... -
An expedition through local and global features of intrinsically disordered proteins using computational lenses
The traditional view in Structural Biology centered on the “one sequence–one structure–one function” paradigm, which emphasized a unique, folded state of protein as the basis for its biological activity. However, this ... -
Exploration of some components of fatty acid biosynthesis in prokaryotes and eukaryotes : PANK of homo sapiens and fabl of plasmodium falciparum
Coenzyme A (CoA) is a central molecule that plays a key role in this process. In the course of this project, we have attempted to address some key questions that deal with an enzyme involved in CoA biosynthesis (Pantothenate ... -
Exploration of the Recombination Repair Pathway in Mycobacteria : Identification and Characterization of New Proteins
Genomic integrity is a fundamental requisite for survival and proliferation of all organisms. The genetic material is continuously threatened by a multitude of extrinsic and intrinsic factors. Consequently, the presence ... -
Exploring Nature's Inventory: Investigating the Role of Amide to Thioamide Substitution on Protein Stability
The peptide backbone holds a protein together and plays a crucial role in guiding its three-dimentional structure. The tertiary structure of proteins regulates several biological processes. Therefore, peptide bond modification ... -
Exploring Protein-Nucleic Acid Interactions Using Graph And Network Approaches
(2009-09-22)The flow of genetic information from genes to proteins is mediated through proteins which interact with the nucleic acids at several stages to successfully transmit the information from the nucleus to the cell cytoplasm. ... -
Exploring The Role Of The Highly Conserved Residues In Triosephosphate Isomerase
(2014-08-11)This thesis discusses the structure-function studies on triosephosphate isomerase (TIM) from Plasmodium falciparum (Pf), directed towards understanding the roles of highly conserved residues by site derected mutagenesis. ... -
First thorough characterization of the structure, interactions and specificity of an archeal lectin with implication for TB infection
Decades long studies on plant lectins carried out in this laboratory have contributed substantially to glycobiology and helped in the initiation and development of macromolecular crystallography in India. Subsequently the ... -
Folding Studies On Peanut Agglutinin : A Lectin With An Unusual Quaternary Structure
(2009-03-04)The thesis entitled “Folding studies on Peanut Agglutinin: A lectin with an unusual quaternary structure” deals with the several aspects of the folding of the tetrameric legume lectin Peanut Agglutinin ... -
Functional and structural studies of proteins involved in telomere maintenance
The linear ends of the eukaryotic chromosomes are protected by a specialized nucleoprotein complex known as telomere. Telomeres consist of telomere DNA and telomere DNA binding proteins (known as shelterin complex). The ... -
Functionally Interacting Proteins : Analyses And Prediction
(2016-05-04)Functional interaction of proteins is a broad term encompassing many different types of associations that are observed amongst proteins. It includes direct non-covalent interactions where the interacting proteins physically ... -
Further Structural Studies on Jacalin and Genomics Search for Mycobacterial and Archeal Lectins
(2017-12-03)This thesis consists of two parts. The first part is concerned with further structural and related studies of jacalin, one of the two lectins found in jack fruit seeds. The second part deals with the search of mycobacterial ...