Browsing Molecular Biophysics Unit (MBU) by Subject "Biochemistry"
Now showing items 41-60 of 74
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Protein NMR Studies of E. Coli IlvN and the Protease-VPg Polyprotein from Sesbania Mosaic Virus
(2018-04-03)Acetohydroxyacid synthase is a multisubunit enzyme that catalyses the first committed step in the biosynthesis of the branched chain amino acids viz., valine, leucine and isoleucine. In order to understand the structural ... -
Protein-DNA Graphs And Interaction Energy Based Protein Structure Networks
(2013-01-29)Proteins orchestrate a number of cellular processes either alone or in concert with other biomolecules like nucleic acids, carbohydrates, and lipids. They exhibit an intrinsic ability to fold de novo to their functional ... -
Solution NMR Studies Of E.Coli Acetohydroxy Acid Synthase (AHAS) I
(2010-04-13)Branched chain amino acids are classified as essential amino acids since their biosynthetic routes or pathways are restricted only to micro-organisms, fungi and plants. Given their unique distribution, the enzymes of the ... -
Solution NMR Studies Of Peptide Toxins From Cone Snails And Scorpion
(2010-09-13)Major constituents of the venom of various animals are peptidogenic in nature. Marine snails belonging to the species Conus are venomous predators that use small, structurally constrained peptides present in their venom ... -
Starvation Response In Mycobacterium Smegmatis : A Tale Of Two Proteins
(2010-10-19)The Dps (DNA-Binding Protein from Starved Cells) proteins are a class of stress-specific proteins with a major role in protecting DNA during the stationary phase of bacterial growth, through direct physical binding as well ... -
Structural And Evolutionary Studies On Protein-Protein Interactions
(2014-05-27)The last few decades have witnessed an upsurge in the availability of large-scale data on genomes and genome-scale information. The development of methods to understand the trends and patterns from large scale data promised ... -
Structural And Functional Analysis Of Proteins With The Double Stranded β-helix (Cupin) Domains
(2010-12-24)Proteins performing catalytic roles predominantly occur in a few protein folds. Functional diversity within a common structural scaffold has been attributed to conformational features that enable exploration of reaction ... -
Structural and Functional Studies on Pyridoxal 5′-Phosphate Dependent Lyases and Aminotransferases
(2017-11-30)The thesis describes structural and functional studies of two PLP-dependent enzymes, diaminopropionate (DAP) ammonia lyase (DAPAL) and N-acetylornithine aminotransferase (AcOAT). The main objective of this work was to ... -
Structural And Functional Studies On Staphylococcus Aureus Enzymes Involved In L-Lysine Biosynthesis
(2011-05-24)Proteins associated with metabolic pathways have received considerable attention in an effort to understand the molecular details of the complex reactions catalyzed in vivo. Enzymes belonging to these pathways have also ... -
Structural And Mechanistic Studies On Receptor Protein Tyrosine Phosphatases From Drosophila Melanogaster
(2013-06-20)Protein Tyrosine Phosphatases (PTPs) initiate, modulate and terminate key cellular processes by dephosphorylating phosphotyrosine (pY) residues on signaling proteins. The coordinated action of PTPs with their cognate ... -
Structural Characterization Of Protein Folding Intermediates
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Structural Studies On Basic Winged Bean Agglutinin
(2009-07-03)The journey of structural studies on lectins, starting with ConA in the 70s, has crossed many milestones. Lectins, multivalent carbohydrate-binding proteins of non-immune origin, specifically bind diverse sugar structures. ... -
Structural Studies On Enzymes From Salmonella Typhimurium Involved In Propionate Metabolism: Biodegradative Threonine Deaminase, Propionate Kinase And 2-Methylisocitrate Lyase
(2007-11-23)I formally joined Prof. M. R. N. Murthy’s laboratory at the Molecular Biophysics Unit, Indian institute of Science, on 1st August 2001. During that time, the interest in the laboratory was mainly focused on structural ... -
Structural Studies on Mycobacterial Aspartic Proteinases and Adenylyl Cyclases
(2018-04-11)Structural investigations on two mycobacterial enzymes were carried out. Tuberculosis still remains a major threat to mankind even though drugs against it have been in use for many decades. The emergence of drug resistant ... -
Structural Studies on Thiolases and Thiolase-like Proteins
(2017-11-21)The genus Mycobacterium comprises some of the most devastating pathogens that infect humans. Mycobacterium tuberculosis causes tuberculosis in humans leading to high morbidity and mortality. The disease is especially ... -
Structural Studies On Three Pyridoxal-5'-Phosphate Dependent Enzymes : N-Acetylornithine Aminotransferase, Serine Hydroxymethyltransferase And Diaminopropionate Ammonia Lyase
(2009-09-02)Pyridoxal 5’-phosphate (PLP), the active form of vitamin B6, is a cofactor for many enzymes involved in the metabolism of amino acids, amino acid derived metabolites and some amino sugars. PLP is one of the most versatile ... -
Structural Studies On Three-Fold Symmetric Plant Lectins
(2013-05-21)Lectins, multivalent carbohydrate-binding proteins of non-immune origin, have the unique ability to decode the information contained in complex carbohydrate structures of glycoproteins and glycolipids by stereo-specifically ...