Browsing Molecular Biophysics Unit (MBU) by Title
Now showing items 19-38 of 393
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Characterizing the link between dynamics and function in proteins that violate the structure-function paradigm
The structure-function paradigm states that the three-dimensional structure of a protein is dictated by its amino acid sequence, which influences its function. However, this paradigm fails to explain the behaviour of ... -
Cholinergic-receptor-independent modulation of intrinsic properties of subicular neurons through inhibition of hyperpolarization-activated cyclic nucleotide-gated channels
Acetylcholine release is vital in tuning the hippocampal theta oscillations. Subiculum, the output region of the hippocampus endowed with different neuronal subtypes, also generates theta oscillations during arousal and ... -
Compact alwin grammar and algorithms for computer coding of organic chemical structures
Abstract not available -
Comparative analyses of homologous protein sequences and structures : Inference on protein evolution
Proteins are linear polymers composed of 20 different amino acid residues and can fold into complex three-dimensional (3D) structures. For a given protein, the information required to fold into a precise 3D structure is ... -
Components Of Fatty Acid Synthesis In Plasmodium Falciparum
(2008-10-17)The disease malaria afflicts more than a billion people and kills almost one to three million of them every year. Of the four species of Plasmodium affecting man viz., P. falciparum, P. vivax, P. ovale and P. malariae, ... -
Computational Analyses of Protein Structure and Immunogen Design
(2018-08-20)The sequence of a polypeptide chain determines its structure which in turns determines its function. A protein is stabilized by multiple forces; hydrophobic interaction, electrostatic interactions and hydrogen bond formation ... -
Computational Analyses Of Proteins Encoded In Genomes Of Pathogenic Organisms : Inferences On Structures, Functions And Interactions
(2015-02-04)The availability of completely sequenced genomes for a number of organisms provides an opportunity to understand the molecular basis of physiology, metabolism, regulation and evolution of these organisms. Significant ... -
Computational And Biochemical Studies On The Enzymes Of Type II Fatty Acid Biosynthesis Pathway : Towards Antimalarial And Antibacterial Drug Discovery
(2009-08-13)Malaria, caused by the parasite Plasmodium, continues to exact high global morbidity and mortality rate next only to tuberculosis. It causes 300-500 million clinical infections out of which more than a million people succumb ... -
Computational And Experimental Studies On Protein Structure, Stability And Dynamics
(2014-08-18)The work in this thesis focuses on the study of three main aspects of proteins, viz, Protein structure, stability, and dynamics. Chapter 1 is a general introduction to the topics studied in this thesis. Chapter 2 deals ... -
Computational Investigation of Heterogeneous Lateral Organisation in Biological Membrane
The study of lateral heterogeneity on membrane surface has come a long way from the fluid mosaic model. Simulations and experimental studies have observed non-random mixing of lipids and proteins in the membrane. In this ... -
Computational investigation of peripheral membrane protein "Pleckstrin homology domain" and its regulation
The peripheral membrane protein repertoire is around 25% composed of the Pleckstrin homology domain (PHD). PHD are component of the multidomain protein and plays the role of an adaptor in recruitment of these proteins ... -
Computational studies on interacting proteins with special reference to toxin-antitoxin systems
Proteins interact with other proteins to maintain functional homeostasis of the cell by tightly regulating cellular processes. Hence, it becomes important to understand not only the downstream effects of protein-protein ... -
Computer Modeling and Molecular Dynamics Simulation Of Angiogenins And Its Ligand Bound Complexes
(Indian Institute of Science, 2006-05-04)Computational structural biology Even with rapid advances in structure determination methods, there is a long gap to be bridged between the number of proteins that have been sequenced and the number whose three-dimensional ... -
Computer modelling approach to study the mode of binding of flavins to flavodoxin
Abstract not available -
Computer Modelling Studies On DNA Triple Helices
(2013-07-22) -
Computer modelling studies on guanine-rich quadruplexes
On the basis of these MD studies, it can be concluded that parallel G-quadruplexes are very stable structures, both energetically as well as structurally. Base interaction energy within the G-tetrad, as well as guanine ... -
concanavalin A- Carbohydrate interactions: a computer modelling approach
Lectins are cell-agglutinating, carbohydrate-binding proteins. They began to generate interest when it was discovered in the 1940s that some of them were capable of specifically agglutinating human erythrocytes. Most lectins ... -
Conformation of calcium antagonists and their interaction with model membranes
Calcium antagonists are a class of drugs with diverse chemical identities and a wide range of pharmacological activities. At least four different chemical classes can be identified within this group of drugs. This heterogeneity ...