Browsing Molecular Biophysics Unit (MBU) by Title
Now showing items 14-33 of 393
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Biophysical Studies on Mycobacterium Tuberculosis σ Factor – Regulatory Protein Complexes
Adaptation to external environmental conditions is essential for the survival of a bacterial cell. Bacteria have thus evolved multiple mechanisms to sense environmental stimuli and to couple this information into an ... -
Biophysical Studies On The Plastic And Cooperative Properties Of Single Voltage Gated Na+ And Leak K+ Ion Channels
(2011-03-08)Ion channels are fundamental molecules in the nervous system that catalyze the flux of ions across the cell membrane. There are mounting evidences suggesting that the kinetic properties of ion channels undergo activity-dependent ... -
CcdB : Stability, folding and application to design novel antibacterials
The primary amino acid sequence typically dictates the ultimate conformation of the protein. Mutations in the sequence demonstrate neutral, positive or negative effects on the structure-function relationship of the protein. ... -
Cell Surface Of Mycobacterium Smegmatis At The Stationary Phase : Regulation Of Gene Expression
(2009-05-21)Tuberculosis remains one of the oldest diseases known to mankind but still persists as a very major risk. Discovery of several antimycobacterials was marked by a steady decline in the active cases of pulmonary tuberculosis. ... -
Characterization of a Staphylococcus aureus multi-enzyme complex involved in the phenotypic switch and host-pathogen interactions
RNA homeostasis is maintained by synchronizing RNA synthesis and RNA degradation. These processes are synchronized to growth conditions and environmental stimuli, thus enabling bacterial survival in diverse environmental ... -
Characterizing the link between dynamics and function in proteins that violate the structure-function paradigm
The structure-function paradigm states that the three-dimensional structure of a protein is dictated by its amino acid sequence, which influences its function. However, this paradigm fails to explain the behaviour of ... -
Cholinergic-receptor-independent modulation of intrinsic properties of subicular neurons through inhibition of hyperpolarization-activated cyclic nucleotide-gated channels
Acetylcholine release is vital in tuning the hippocampal theta oscillations. Subiculum, the output region of the hippocampus endowed with different neuronal subtypes, also generates theta oscillations during arousal and ... -
Compact alwin grammar and algorithms for computer coding of organic chemical structures
Abstract not available -
Comparative analyses of homologous protein sequences and structures : Inference on protein evolution
Proteins are linear polymers composed of 20 different amino acid residues and can fold into complex three-dimensional (3D) structures. For a given protein, the information required to fold into a precise 3D structure is ... -
Components Of Fatty Acid Synthesis In Plasmodium Falciparum
(2008-10-17)The disease malaria afflicts more than a billion people and kills almost one to three million of them every year. Of the four species of Plasmodium affecting man viz., P. falciparum, P. vivax, P. ovale and P. malariae, ... -
Computational Analyses of Protein Structure and Immunogen Design
(2018-08-20)The sequence of a polypeptide chain determines its structure which in turns determines its function. A protein is stabilized by multiple forces; hydrophobic interaction, electrostatic interactions and hydrogen bond formation ... -
Computational Analyses Of Proteins Encoded In Genomes Of Pathogenic Organisms : Inferences On Structures, Functions And Interactions
(2015-02-04)The availability of completely sequenced genomes for a number of organisms provides an opportunity to understand the molecular basis of physiology, metabolism, regulation and evolution of these organisms. Significant ... -
Computational And Biochemical Studies On The Enzymes Of Type II Fatty Acid Biosynthesis Pathway : Towards Antimalarial And Antibacterial Drug Discovery
(2009-08-13)Malaria, caused by the parasite Plasmodium, continues to exact high global morbidity and mortality rate next only to tuberculosis. It causes 300-500 million clinical infections out of which more than a million people succumb ... -
Computational And Experimental Studies On Protein Structure, Stability And Dynamics
(2014-08-18)The work in this thesis focuses on the study of three main aspects of proteins, viz, Protein structure, stability, and dynamics. Chapter 1 is a general introduction to the topics studied in this thesis. Chapter 2 deals ... -
Computational Investigation of Heterogeneous Lateral Organisation in Biological Membrane
The study of lateral heterogeneity on membrane surface has come a long way from the fluid mosaic model. Simulations and experimental studies have observed non-random mixing of lipids and proteins in the membrane. In this ... -
Computational investigation of peripheral membrane protein "Pleckstrin homology domain" and its regulation
The peripheral membrane protein repertoire is around 25% composed of the Pleckstrin homology domain (PHD). PHD are component of the multidomain protein and plays the role of an adaptor in recruitment of these proteins ... -
Computational studies on interacting proteins with special reference to toxin-antitoxin systems
Proteins interact with other proteins to maintain functional homeostasis of the cell by tightly regulating cellular processes. Hence, it becomes important to understand not only the downstream effects of protein-protein ... -
Computer Modeling and Molecular Dynamics Simulation Of Angiogenins And Its Ligand Bound Complexes
(Indian Institute of Science, 2006-05-04)Computational structural biology Even with rapid advances in structure determination methods, there is a long gap to be bridged between the number of proteins that have been sequenced and the number whose three-dimensional ...