The genome in prokaryotes is restricted to a membrane-less compartment termed nucleoid. The genome is maintained in the compacted state within the nucleoid with the help of three key cellular factors viz, macromolecular ...

DNA encounters topological constraints during essential cellular processes such as replication, transcription, and chromosome segregation. To ensure facile execution of these processes, a ubiquitous class of enzymes known ...

Foamy macrophages or Foam cells are a critical cellular component of the granuloma formed during pulmonary infection. These lipid rich cells generally contain neutral lipids, Cholesteryl Esters (CE) and/or Triglycerides ...

Mycobacterium tuberculosis, the causative agent of tuberculosis, has become a global health concern. This calls for a dire need to understand various aspects of mycobacterial physiology in order to design better strategies ...

Protection conferred by BCG vaccine against adult pulmonary TB ranges from 0–80% based on large, well-controlled field trials. This variability is highly significant (P < 0.0001) and is regarded as being indicative of true ...