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Understanding the mechanisms of polarity establishment and nuclear envelope breakdown in Caenorhabditis elegans embryos
Polarity establishment is critical for the development and stem cell lineages. The one-cell stage of the Caenorhabditis elegans embryo polarizes soon after fertilization. As a result, the first division of the embryo ...
Structure-function and evolution of a unique uracil DNA glycosylase, UdgX, from Mycobacterium smegmatis
Mycobacterium smegmatis, a soil bacterium, faces multiple challenges in its environment, including exposure to reactive oxygen species (ROS), reactive nitrogen intermediates (RNI), radiation, and various other chemical ...
Studies on the translation initiation factors in bacteria and mitochondria
The process of protein synthesis is a fundamental and key event in living organisms. The process of translation initiation is assisted by specific proteins known as initiation factors. In bacteria, three initiation ...
Understanding the mechanism of host deacetylase SIRT1 and SIRT3 in the modulation of Salmonella pathogenesis
Host sirtuins are one of the important modulators of host immuno-metabolic regulation. However, the role of sirtuins in the modulation of the immune metabolism pertaining to Salmonellosis is largely unknown. Here, we ...
Role of Sirtuin 2 in the development of tissue fibrosis
Wound healing is a crucial physiological process required for the healthy lifespan of an
organism. Dysregulation in the process of wound healing leads to the production of excess
extracellular matrix leading to fibrosis. ...
Transcriptional regulation of a microRNA encoding gene MIR319C during leaf development in Arabidopsis thaliana
The evolutionarily conserved microRNA miR319 and its target transcription factors encoded by five CIN-TCPs (TCP2, 3, 4, 10 & 24) regulate leaf morphogenesis in Arabidopsis by triggering the division to differentiation ...
Investigating the role of an atypical dual-specificity phosphatase DUSP28 in mammalian cells
Dual-specificity phosphatases (DUSPs) belong to the protein tyrosine phosphatases (PTP)
subfamily and dephosphorylate, both serine/threonine and tyrosine residues of proteins and
non-protein substrates. A subgroup of ...
Dissecting the function of NuMA in cleavage furrow formation and chromatin decondensation at the mitotic exit in animal cells
In animal cells, the duplicated genetic material is aligned on a microtubule-based structure known as the mitotic spindle during mitosis. At the mitotic exit, the mitotic spindle elongates, and the sister chromatids get ...
Characterization of XRN2-mediated microRNA turnover mechanism and its pathophysiological significance in eukaryotes
MicroRNAs (miRNAs) are endogenous, small non-coding RNAs that are extensively involved in the posttranscriptional regulation of gene expression in eukaryotes. Comprehensive studies on miRNA expression and function have ...
Exploring the roles of nucleoid-associated protein HU and two of its interacting proteins in Mycobacterium tuberculosis pathogenesis
The genome in prokaryotes is restricted to a membrane-less compartment termed nucleoid. The genome is maintained in the compacted state within the nucleoid with the help of three key cellular factors viz, macromolecular ...