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Studies On Phosphorylation And Oligomerization Of Rotavirus Nonstructural Protein 5 (NSP5) And Cellular Pathways That Regulate Virus Replication
(2016-04-28)
Rotavirus is one of the leading etiological agents of gastroenteritis in young of many species including humans worldwide and is responsible for about 600,000 infant deaths per annum. Rotavirus belongs to the Reoviridae ...
Mechanistic And Functional Insights Into Mycobacterium Bovis BCG Triggered TLR2 Signaling : Implications For Immune Evasion Strategies
(2015-09-04)
Mycobacteria are multifaceted pathogens capable of causing both acute disease as well as an asymptomatic latent infection. Host immune responses during mycobacterial infection involve potent cell effector functions including ...
Studies On The Mechanism Of Uracil Excision Repair In Escherichia Coli And Structure-Function Relationship Of Single Stranded DNA Binding Proteins From Escherichia Coli And Mycobacterium Tuberculosis
(2014-12-11)
To maintain the genomic integrity, cell has evolved various DNA repair pathways. Base Excision Repair pathway (BER) is one such DNA repair pathway which is dedicated to protect DNA from small lesions such as oxidation, ...
Fidelity Of Translation Initiation In E. coli : Roles Of The Transcription-recycling Factor RapA, 23S rRNA Modifications, And Evolutionary Origin Of Initiator tRNA
(2016-09-15)
Translation initiation is a rate limiting step during protein biosynthesis. Initiation occurs by formation of an initiation complex comprising 30S subunit of ribosome, mRNA, initiator tRNA, and initiation factors. The ...
Molecular Characterisation Of Mycobacterium Tuberculosis Fic Protein And Its Gene And Identification And Characterisation Of A Novel Functional Interaction Between FtsZ And NDK in Mycobacteria
(2016-04-29)
Living organisms employ different kinds of mechanisms, to regulate the functions of genes or their products, which may help in maintaining homeostasis inside the cell or may help in fighting hostile environment in the case ...
Breast Cancer Susceptibility Gene 1 (BRCA1) And Breast Cancer
(2009-04-15)
Breast Cancer susceptibility gene 1 (BRCA1) & Breast Cancer
Breast cancer is one of the most common malignancies affecting women worldwide. About 5-10% of all cases are estimated to be familial. Mutations in the BRCA1 ...
DNA Gyrase And Topo NM From Mycobacteria : Insights into Mechanism And Drug Action
(2017-10-26)
Maintenance of a topological homeostasis by introduction and removal of the supercoils to
relieve excessive strain on the DNA is a hallmark of topoisomerase function in the cell. The requirement of the topoisomerases during ...
Study Of Rpb4, A Component Of RNA Polymerase II As A Coordinator Of Transcription Initiation And Elongation In S. Cerevisiae
(2017-05-24)
RNA polymerase II (Pol II) is the enzyme responsible for the synthesis of all mRNAs in eukaryotic cells. As the central component of the eukaryotic transcription machinery, Pol II is the final target of transcription ...