Browsing Microbiology and Cell Biology (MCB) by thesis submitted date"2014"
Now showing items 1-15 of 15
-
Characterization of Host Protein Interactions with HCV RNA : Implications in Viral Translation, Replication and Design of Antivirals
(2018-05-09)HCV genome is a positive sense single-stranded RNA containing a single open reading frame (ORF) flanked by untranslated regions (UTRs), 5’UTR and 3’UTR.Initiation of HCV RNA translation is mediated by internal ribosome ... -
Design and Application of Temperature Sensitive Mutants in Essential Factors of RNA Splicing and RNA Interference Pathway in Schizosaccharomyces Pombe
(2018-05-10)Gene deletions are a powerful method to uncover the cellular functions of a given gene in living systems. A limitation to this methodology is that it is not applicable to essential genes. Even for non-essential genes, gene ... -
DNA Gyrase And Topo NM From Mycobacteria : Insights into Mechanism And Drug Action
(2017-10-26)Maintenance of a topological homeostasis by introduction and removal of the supercoils to relieve excessive strain on the DNA is a hallmark of topoisomerase function in the cell. The requirement of the topoisomerases during ... -
DNA Repair Proteins in Mycobacteria and their Physiological Importance
(2018-03-09)DNA repair proteins in mycobacteria and their physiological importance Mycobacterium tuberculosis, the causative organism of tuberculosis, resides in the host macrophages where it is subjected to a plethora of stresses ... -
From Transformation to Therapeutics : Diverse Biological Applications of Shock Waves
(2018-02-26)Chapter–I Introduction Shock waves appear in nature whenever the different elements in a fluid approach one another with a velocity larger than the local speed of sound. Shock waves are essentially non-linear waves that ... -
Functional Characterization of RFL as a Regulator of Rice Plant Architecture
(2018-03-09)Poaceae (or Gramineae) belong to the grass family and is one of the largest families among flowering plants on land. They include some of the most important cereal crops such as rice (Oryza sativa), barley (Hordeum vulgare), ... -
Functional Characterization of Saccharomyces Cerevisiae SUB1 in Starvation Induced Sporulation Response
(2017-12-12)Among the various external signals perceived by yeast cells, nutrient availability is a condition to which these cells show a highly diverse biological response. Diploid cells in response to different nutritional stress ... -
Immune Evasion and Survival Strategies of Mycobacterium : Role for Host Signaling Pathway-Mediated Micro RNAs and Epigenetic Regulation
(2018-05-09)The genus Mycobacterium represents more than 120 species of bacteria including the pathogenic M. tuberculosis, the etiological agent of tuberculosis. The host mounts a robust inflammatory and cell-mediated response to ... -
Map-based Cloning and Characterization of TARANI, a Global Regulator of Arabidopsis Development
(2018-03-02)Forward genetic screen was performed in Arabidopsis thaliana to isolate novel genes involved in leaf development. The tarani (tni) mutant was selected for further study based on its unique cup-shaped lamina with +ve Gaussian ... -
Mechanistic Insights into Translation and Replication of Hepatitis C Virus RNA : Exploring Direct-Acting Antivirals
(2018-03-09)Hepatitis C virus (HCV), a blood-borne pathogen, is a small enveloped RNA virus belonging to the Hepacivirus genus of the Flaviviridae family. HCV infection represents one of the major health concerns affecting approximately ... -
Nucleoid-associated Proteins of Mycobacterium tuberculosis : Insights into their Functions
Bacteria face the challenging task of compacting their chromosomes to accommodate them in a small cytoplasmic volume and at the same time maintaining the nucleoids in a highly organized and dynamic state for transcription, ... -
Racemases in Salmonella : Insights into the Dexterity of the Pathogen
(2018-02-27)Chapter -I Introduction Salmonella is a pathogen well-known for its ability to infect a wide variety of hosts and causes disease ranging from mild gastroenteritis to typhoid fever. During infection, it is exposed to a ... -
Regulation of the Principal Cell Division Protein FtsZ of Escherichia Coli by Antisense RNA and FtsH Protease
(2018-05-10)The PhD thesis is on the studsy of the influence of the ftsZ antisense RNA and FtsH protease on the synthesis and function of the Escherichia coli cytokinetic protein, FtsZ, which mediates septation during cell division. ... -
Topoisomerases from Mycobacteria : Insights into the Mechanism, Regulation and Global Modulatory Functions
(2018-03-09)The eubacterial genome is maintained in a negatively supercoiled state which facilitates its compaction and storage in a small cellular space. Genome supercoiling can potentially influence various DNA transaction processes ... -
Transcription Initiation and its Regulation in Mycobacterium Tuberculosis
(2018-02-27)The ability to fine-tune gene-expression in the adverse conditions during pre and post infectious stages has contributed in no small measure to the success of Mycobacterium tuberculosis as the deadly pathogen. Multiple ...