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Regulation of Lateral Mobility of Amyloid Precursor Protein by an Alzheimer’s Disease Risk Gene: Picalm
Amyloid Precursor Protein (APP) is implicated in several functions in neurons, but the altered processing of APP in synapses holds a key to understanding the onset of the molecular progression of Alzheimer’s Disease (AD). ...
Neural Mechanisms underlying the planning of sequential saccades
Saccades are rapid eye movements that we continually make (about 2-3 times per second) to look around and scan our visual environment. Though we effortlessly execute saccadic eye movements all the time, they are not just ...
Novel Therapeutic Targets for Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by
impaired memory and other cognitive deficits. Even though the genes associated with
familial AD were discovered more than three decades ...
Optical and behavioural tools to investigate the neural correlates of learning and memory
Events in our everyday life are encoded as memories that can be consciously recollected and remembered, although our ability to retrieve the specific details associated with these events diminish with time. Such losses ...
Role of calcium sensors in differential alignment of synaptic nanomachinery during neurotransmission
Some of the brain's most remarkable feats such as learning and memory, are thought to emerge from elementary properties of chemical synapses. The distinctive feature of these synapses is that the action potential in the ...