Amyloid beta, a key determinant in the pathology of Alzheimer's disease (AD), is formed by the sequential proteolysis of Amyloid Precursor Protein (APP) by β-and γ-secretase. Evidence over the last few decades indicates ...

Amyloid Precursor Protein (APP) is a key player in Alzheimer’s disease (AD). Despite intuitive insights into differential proteolysis of APP, there is a little understanding of how the amyloidogenic machinery is distributed ...

Amyloid Precursor Protein (APP) is implicated in several functions in neurons, but the altered processing of APP in synapses holds a key to understanding the onset of the molecular progression of Alzheimer’s Disease (AD). ...