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Aβ42-mediated dendritic spine loss in an in-vitro model of Alzheimer’s disease
The results from this study establish the molecular mechanism underlying the Aβ42-mediated dendritic spine loss observed in the APP/PS1 mouse model of AD. Further, this study highlights the role of Aβ42 in altering the ...
Estimation of the spatial spread of brain signals at multiple scales
Spatial spread of a particular brain signal can be defined as the area of the cortical tissue around
the recording electrode that contributes to the electrical activity recorded by the electrode. More
specifically, ...
Structure-Function Analysis of Focal Adhesion Protein Vinculin in Neocortical Axon Growth and Development
Axon growth and extension are dependent on the interaction of neurons with extracellular matrix (ECM). The interaction between cells and ECM is known as focal adhesion (FA). Vinculin is one the major proteins of FA complex ...
SRF regulates the generation of neuroprotective astrocytes in the brain
In response to injuries, infections or in neurodegenerative disorders, astrocytes get activated to become reactive. This phenomenon is called astrogliosis and is marked by a spectrum of changes which encompasses structural, ...
Neural Correlates and Behavioral Underpinnings of Remote Memories during Systems Consolidation
Remote retrieval of declarative memories has been under investigation for a long time. After acquisition, long-term encoding of memories happens through crosstalk across multiple brain regions. Through systems consolidation, ...
Use of Human Induced Pluripotent Stem Cells as a Model to Study Primary Microcephaly
The aim of this study was to use human induced pluripotent stem cells (hiPSC) to understand key steps of neuronal differentiation and to model the human brain developmental disorder, primary microcephaly (MCPH). MCPH is a ...
Role of Mint family of Proteins in the nanoscale localization and real-time retention of surface Amyloid Precursor
Amyloid beta, a key determinant in the pathology of Alzheimer's disease (AD), is formed by the sequential proteolysis of Amyloid Precursor Protein (APP) by β-and γ-secretase. Evidence over the last few decades indicates ...
Characterization of Neuroprotective Reactive Astrocytes in the Aging Mammalian Brain
The brain manifests cognitive deficits in aging and becomes more vulnerable to neurodegeneration. Astrocytes play several critical roles in the brain, including synapse formation, maturation, elimination, and synaptic ...
Parietal and prefrontal control of distinct components of attention
In this thesis, we investigate behavioural mechanisms and neural substrates of distinct components of endogenous spatial attention. Endogenous attention facilitates neural processing of the selected stimulus through one ...
Effect of Stimulus Normalization and Visual Attention at multiple scales of Neural Integration
The effect of visual attention on neural signals has been extensively studied using various techniques such as macaque neurophysiology and human electro/magneto encephalogram (EEG/MEG). Depending on the technique, different ...