Browsing Centre for Neuroscience (CNS) by Subject "Research Subject Categories::NATURAL SCIENCES::Biology::Cell and molecular biology::Neurobiology"
Now showing items 1-11 of 11
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Astrocytes regulate oligodendrocyte development and myelination in the mammalian brain
Oligodendrocytes (OLs), a type of glial cell, are the main myelinating cells of the mammalian central nervous system (CNS), enabling efficient saltatory mode of nerve conduction. On the other hand, astrocytes, another glial ... -
Behavioural and neural signatures of interactions between conflicting emotion and reward
Reward-related events seldom occur in isolation in our everyday lives — a component of emotion processing remains intertwined in many cases. For instance, individuals often work under hostile conditions for higher pay or ... -
Characterization of Neuroprotective Reactive Astrocytes in the Aging Mammalian Brain
The brain manifests cognitive deficits in aging and becomes more vulnerable to neurodegeneration. Astrocytes play several critical roles in the brain, including synapse formation, maturation, elimination, and synaptic ... -
Circuit mechanisms of itch modulation: from physiology to pathology
Itch is a distinct somatosensation, evoked by chemical and mechanical pruritogens or psychosomatic factors. It detects harmful sensory stimuli and triggers scratching to remove irritants from the skin. However, chronic ... -
How does familiarity change visual object representations ?
Familiarity with something implies having a close acquaintance with that item, generally acquired over a period of time. Apart from single items, we have experienced getting familiar with a pair of items (like a mouse and ... -
Investigating mechanisms underlying astrocytic involvement in depressive-like behavior and antidepressant action
Major Depressive disorder (MDD) is a complex, multifactorial psychiatric illness which affects over 20% of the population worldwide. Despite its prevalence, our understanding of its pathophysiology is severely limited, ... -
Investigating the neural basis of spatial attentional components with probabilistic and reward cueing
We are constantly inundated with an abundance of sensory information. “Attention” enables the selection of relevant information and filtering out irrelevant information, to guide adaptive behavior. While attention can be ... -
PSD95 as a biophysical modulator of synaptic communication
PSD95 is a core scaffold protein of the postsynaptic density (PSD) at excitatory synapses and a member of the MAGUK family, where it plays a central role in organizing glutamate receptors, ion channels, and signalling ... -
Shared and distinct mechanisms of saccade preparation, external and internal attention
Everyday activities – like reading an email, watching a football match, scrolling through social media, or window-shopping – all involve quickly scanning complex visual scenes using rapid eye movements called “saccades.” ... -
Studying induced and evoked oscillations for probing visual and auditory circuit mechanisms
Specialized sensory regions process incoming sensory inputs using a variety of mechanisms, such as normalization and excitatory-inhibitory interactions. These mechanisms can be studied through induced and evoked oscillations, ... -
Tuning the Circuit, Steering the Swarm: CASY-1 in Synaptic and Behavioral Modulation
Disruptions in neuromodulatory signaling are a hallmark of several neurodevelopmental and psychiatric disorders. However, the molecular mechanisms that fine-tune neuromodulation across circuits and behaviors remain poorly ...