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dc.contributor.advisorJayaraman, Narayanaswamy
dc.contributor.authorYadav, Shivender
dc.date.accessioned2022-11-30T06:26:52Z
dc.date.available2022-11-30T06:26:52Z
dc.date.submitted2022
dc.identifier.urihttps://etd.iisc.ac.in/handle/2005/5928
dc.description.abstractOverall, the Thesis work establishes: • Monomeric and multimeric ligand-lectin interactions occurring at cell surfaces that could be assessed using purified protein and cellular model system, namely, glycovesicles; • Variation in the ligand density as a hallmark to switch the nature of the interaction between monomeric and multimeric ligand-lectin interactions; • Sparsely populated ligand surfaces promote intermolecular aggregation of the ligand-lectin complex, whereas mostly or fully ligand-functionalized surfaces involve intracellular monomeric ligand-lectin complex formation; • That the binding affinities between intra- and intervesicular modes are comparable, yet the intravesicular mode tend to have a higher binding affinity; • That introduction of amphiphilicity through incorporating sugar moieties on PDA polymers is a viable approach to induce mesomorphism in PDA polymers; • Structural characterization and modeling studies on lamellar arrangement and interdigitization of the glycolipids in the mesophase; • Smectic layering which occurs commonly in glyco-PDAs. The mesophase temperature range and the structural ordering are observed to vary depending on the sugar moietyen_US
dc.language.isoen_USen_US
dc.rightsI grant Indian Institute of Science the right to archive and to make available my thesis or dissertation in whole or in part in all forms of media, now hereafter known. I retain all proprietary rights, such as patent rights. I also retain the right to use in future works (such as articles or books) all or part of this thesis or dissertationen_US
dc.subjectCarbohydratesen_US
dc.subjectPolydiacetyleneen_US
dc.subjectLiquid crystalsen_US
dc.subject.classificationResearch Subject Categories::NATURAL SCIENCES::Chemistry::Organic chemistry
dc.titleSynthesis and Studies of Covalent Polydiacetylene Glycopolymers as Scaffolds to Uncover Intricate Carbohydrate-Protein Interactionsen_US
dc.typeThesisen_US
dc.degree.namePhDen_US
dc.degree.levelDoctoralen_US
dc.degree.grantorIndian Institute of Scienceen_US
dc.degree.disciplineFaculty of Scienceen_US


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