C-H Bond Functionalization and Tandem Cyclization with Alkynoates and Maleimides Using Directing Group Strategy

Abstract

The thesis presents manganese‒ and rhodium‒catalyzed C‒H bond activation and tandem cyclization reactions. These reactions lead to the construction of carbon‒carbon bonds using directing group strategy. The thesis is divided into two sections. Section‒A is presented in three chapters, which describes the C‒H bond functionalization of N‒pyrimidylindoles, imines, and benzoic/acrylic acids with 4‒hydroxy‒2‒alkynoate as a coupling partner. This alkynoate is a highly functionalized unsymmetrical internal alkyne that can undergo regioselective alkenylation/annulation and lactonization after C‒H bond activation. The developed reactions are highly efficient, step economical, and require a single set of reaction conditions. Section‒B is presented in two chapters employing maleimides as a coupling partner with 2‒alkenylphenols and sulfoximines for [5+1] and diastereoselective [4+1] spirocyclization reactions, respectively, using Rh(III)‒catalytic system.