| dc.contributor.advisor | Muniyappa, K | |
| dc.contributor.author | Thakur, Manoj | |
| dc.date.accessioned | 2021-10-27T05:09:18Z | |
| dc.date.available | 2021-10-27T05:09:18Z | |
| dc.date.submitted | 2018 | |
| dc.identifier.uri | https://etd.iisc.ac.in/handle/2005/5486 | |
| dc.description.abstract | This thesis is presented in three chapters divided by topics. Chapter I will begin with an overview of literature regarding different types of DNA damage, DNA repair pathways in bacteria, properties of E. coli UvrABC subunits and their DNA damage-detection capabilities. Thereafter, the chapter will briefly discuss the biological significance, cellular responses as well as the components of NER pathway in M. tuberculosis. Chapter II and III follow a similar organization, presented in the following order: summary of the results, introduction and aims of the study, results and discussion. Specifically, in Chapter II, the biochemical and functional characterization of wild-type and variants of M. tuberculosis UvrB are presented. Chapter III includes biochemical and functional characterization of wild-type and variants of M. tuberculosis UvrC | en_US |
| dc.language.iso | en_US | en_US |
| dc.relation.ispartofseries | ;G29346 | |
| dc.rights | I grant Indian Institute of Science the right to archive and to make available my thesis or dissertation in whole or in part in all forms of media, now hereafter known. I retain all proprietary rights, such as patent rights. I also retain the right to use in future works (such as articles or books) all or part
of this thesis or dissertation | en_US |
| dc.subject | Escherichia coli | en_US |
| dc.subject | nucleotide excision repair | en_US |
| dc.subject | tuberculosis | en_US |
| dc.subject | UvrC | en_US |
| dc.subject | UvrABC | en_US |
| dc.subject.classification | Research Subject Categories::NATURAL SCIENCES::Chemistry::Biochemistry | en_US |
| dc.title | Conservation and divergence of the nucleotide excision repair pathway: Comparison of UvrB and UvrC proteins from Mycobacterium tuberculosis and Escherichia coli reveal significant differences in their functional properties | en_US |
| dc.type | Thesis | en_US |
| dc.degree.name | PhD | en_US |
| dc.degree.level | Doctoral | en_US |
| dc.degree.grantor | Indian Institute of Science | en_US |
| dc.degree.discipline | Faculty of Science | en_US |
