Regioselective C-H Amidation Reactions using Directing Group Strategy and its Application in Organic Synthesis

Abstract

The thesis represents an approach for the C-H bond activation using directing group strategy. The C-H activation happens through five/six-membered metallacycle through concerted metallation deprotonation. Further functionalization leads to C-N formation in the presence of an amidating reagent dioxazolone. Dioxazolone a robust and efficient amidating reagent has been utilized for the C-N bond formation reaction. The strategy has been applied for the azobenzene derivatives for further benzotriazole heterocycle synthesis. The 7-amino indoline derivatives have been synthesized at the ambient condition which endures an application in bioactive molecules. Subsequently, the amidated 2-amido aldehydes and ketones derivatives have been utilized for the synthesis of quindolinone alkaloids