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Molecular Insights into the Structure and Function of Pepper Vein Banding Virus Encoded Proteins and Endocytic Uptake Pathway of Virus-like Particles into Mammalian Cells
Viruses are major pathogenic agents that cause a variety of diseases in all living systems. Since their first isolation in 1892 by Dimitrii Ivanovsky, methods of their diagnosis and control, their life cycles, host - virus ...
Targeting RAD51C Pathological Mutants by Synthetic Lethality and Extended Functions of RAD51C/XRCC3 in Mitochondrial Genome Maintenance
To counteract the potentially calamitous effects of genomic instability in the form of double-strand breaks (DSBs), cells have evolved with two major mechanisms. First, DNA non¬homologous end joining (NHEJ) which requires ...
Understanding the Role of ThiJ/DJ-1/PfpI Family Member Proteins in Regulating Redox Homeostasis, Mitochondrial Health and Lifespan in Saccharomyces cerevisiae
In a healthy cell, the ROS levels are stringently regulated by the action of various enzymatic or non-enzymatic antioxidant systems. Imbalance in the ROS homeostasis generates oxidative stress resulting in damage to cellular ...
Characterization of mouse Apolipoprotein L9 and investigation of its cellular functions
This thesis is divided into 3 chapters.
Chapter 1, titled General Introduction, is a chapter that familiarizes the reader with
the general subject matter of the thesis so that the content of Chapters 2 and 3 can ...
Unraveling the Intricate Architecture of Human Mitochondrial Presequence Translocase - Insights on its Evolution and Role in Tumourigenesis
(2018-04-23)
The present thesis focuses on the elucidation of human mitochondrial inner membrane presequence-translocation machinery with implications on cancer cell proliferation. Mitochondria are the endosymbiotic organelles in an ...
Understanding the structural organization of the carrier translocase machinery in regulating mitochondrial biogenesis and organelle quality control
Mitochondria are essential eukaryotic organelles required for diverse cellular functions including, energy homeostasis, iron-sulfur cluster biogenesis, and signaling. Therefore, the maintenance of organelle quality control ...
Translational readthrough of AGO1 mRNA and its regulation by let-7a microRNA
During translation, the message encoded in mRNAs is decoded by ribosomes to synthesize proteins following strict canonical decoding rules. This process is tightly regulated and several mechanisms exist in cells that ensure ...
Stop codon readthrough in MTCH2 mRNA and its role in mitochondrial physiology
Stop codon readthrough is the process in which translation continues beyond a stop codon till a downstream, in-frame stop codon generating a polypeptide with a C-terminal extension. MTCH2 was selected as a potential ...
Understanding Heat Shock Protein 90 Biology And Exploring Its Potential As A Target Against Neglected Protozoan Diseases
(2013-04-04)
Cells invest a lot of energy in order to get their proteins to fold correctly and attain functionality. It is the functional proteome of a cell that defines the ‘life of a cell’. Cells have therefore employed dedicated ...
Large-Scale Structural Analysis of Protein-ligand Interactions : Exploring New Paradigms in Anti-Tubercular Drug Discovery
(2018-08-13)
BIOLOGICAL processes are governed through specific interactions of macromolecules. The three-dimensional structural information of the macromolecules is necessary to understand the basis of molecular recognition. A large ...