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Biochemical Characterization Of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 Using Telomeric DNA : A Role For The Endonucleolytic Activity Of Mre11 In Telomere Length Maintenance And Its Regulation By Rad50
(2009-05-15)
Meiotic recombination is a prerequisite for exchange of genetic information in all
Sexually reproducing organisms. This process is initiated by the formation of double
stranded breaks (DSBs) in DNA followed by homology ...
Cytotoxic T lymphocyte Responses Against Japanese Encephalitis Virus In Mice: Specificity And Immunotherapeutic Value
(Indian Institute of Science, 2005-10-07)
Cytotoxic T Lymphocytes (CTL) are known to play an important role in clearing infectious virus from infected hosts in a variety of viral infections. Depending on the type of virus and mode of virus entry both class I and ...
Peptidase N, A Major Aminopeptidase Belonging To The M1 Family : Biochemical And Functional Implications
(2009-08-05)
Intracellular protein degradation is required for maintaining the cellular proteome and regulating cellular processes. This pathway involves proximal ATP-dependent proteases that unfold and translocate proteins targeted ...
Study of Ca2+-Mediated Signal Transduction During Embryogenesis In Sandalwood (Santalurm Album L.) And Characterization Of An Early Development-Specific CDPK
(Indian Institute of Science, 2005-12-08)
Calcium ion plays a pivotal role as second messenger during signal/response coupling in plant cells (Trewavas, 1999). Elevations of cytosolic Ca2+ occur in plants as a consequence of abiotic and biotic stresses, environmental ...
Towards The Understanding Of The Structural Biology Of Histone H1
(Indian Institute of Science, 2005-11-23)
In the eukaryotic nucleus, an immense length of DNA is compactly packaged to generate an ordered three-dimensional hierarchical structure called chromatin (van Holde, 1988; Wolffe, A.P, 1998). This organization forms a ...
Identification of Tropomyosin as the Major Cross-Reacting Crustacean Allergen
(Indian Institute of Science, 2005-04-25)
Seafood including crustaceans, on ingestion, are known to provoke gastrointestinal as well as systemic allergic reactions. Crustaceans are aquatic arthropods with a chitinous exoskeleton and include shrimp, lobster, prawn ...
Identification Of Chloroquine Resistant Haplotypes Of Plasmodium Falciparum In India And Development Of New Antimalarial Combinations
(2008-10-03)
Malaria afflicts 300-500 million people in the world and the mortality ranges from 1-2
million, children in Africa being the most susceptible. With a vaccine not being
available against malaria and the front line drugs ...
Type-II Ribosome Inactivating Proteins From Abrus Precatorius : Cytotoxicity And Mechanism Of Cell Death
(2009-05-21)
Type-II Ribosome Inactivating Proteins from Abrus precatorius: Cytotoxicity and Mechanism of Cell Death
A/B toxins produced by bacteria and plants are among the deadliest molecules known. The plant type-II ribosome ...
Virus-Inducible Gene Expression Changes In Mouse Brain : Studies With Japanese Encephalitis & Rabies Viruses
(2009-04-16)
One of the key events in a virus-infected host cell is the activation and repression of a large number of host genes. In recent years, such differentially expressed host genes have been identified for several viruses, ...
Functional Role Of Heat Shock Protein 90 From Plasmodium Falciparum
(2009-03-18)
Molecular chaperones have emerged in recent years as major players in many aspects of cell biology. Molecular chaperones are also known as heat shock proteins (HSPs) since many were originally discovered due to their
increased ...