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Conservation and divergence of the nucleotide excision repair pathway: Comparison of UvrB and UvrC proteins from Mycobacterium tuberculosis and Escherichia coli reveal significant differences in their functional properties
This thesis is presented in three chapters divided by topics. Chapter I will begin with an overview of literature regarding different types of DNA damage, DNA repair pathways in bacteria, properties of E. coli UvrABC ...
Role of Escherichia coli UvrD helicase in resolving G-quadruplex DNA structures
G-quadruplex (G4) secondary structures have been implicated in various biological processes,
including gene expression, DNA replication and telomere maintenance. However,
unresolved G4 structures impede replication ...
Molecular dissection of Komagataella phaffii Rtg1–RtgX function and development of a glutamate-responsive protein expression platform
In Saccharomyces cerevisiae, the basic helix-loop-helix leucine zipper (bHLH-LZ) proteins Rtg1 and Rtg3 form a heterodimeric transcription factor complex that mediates the retrograde response. In Candida albicans, these ...
Studies on the roles of Lon protease and its substrates during antibiotic resistance in Escherichia coli: modulatory effects of nitroaromatics and nitrofurantoin
Bacteria adapt to environmental stresses, including antibiotic stress, by regulating
various genes and metabolic pathways. In prokaryotes, the energy-dependent protein
degradation is controlled primarily by two ...