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Stereochemical And Synthetic Investigations
(2017-05-25)
PART I
RESOLUTION AND DESYMMETRISATION
Chapter I. ‘A Novel Racemate Resolution’. This describes a novel resolution strategy as applied to racemic α-amino acids in the solid state. The strategy is based on the possibility ...
Synthesis And Characterization of Cationic Lipids And Carbon Nanomaterials Based Composites for the Delivery Of Bioactive Oligo/Polynucleotides and Drugs In Vitro and In Vivo
(2017-11-27)
The biggest hurdle in success of gene and drug therapy is designing and preparation of suitable bio-nanomaterials to carry the desired nucleic acid and drug to the targeted site. The work described in the present thesis ...
Construction of Complex Polycyclic Systems using Gold Catalyzed Intramolecular Diyne/Enyne/ Hydroalkoxylation Reactions
(2018-07-18)
First section of chapter 1 deals with gold catalyzed synthesis of ring fused furo[3,2,b]pyrans and furo[3,2,b]furans. Furo[3,2,b]pyrans and furo[3,2,b]furans are ubiquitous structural segments found in a number of natural ...
Total Synthesis of Bio-Active Macrolide Natural Products and Sulfinamide Based Ligands in Asymmetric Catalysis
(2018-07-18)
The thesis entitled “Total synthesis of bio-active macrolide natural products and sulphonamide based ligands in asymmetric catalysis” is divided into two chapters.
First chapter of the thesis describes the total synthesis ...
Palladium Catalyzed Refunctionalizations of Olefins : Novel Strategies for Construction of C-C, C-Hetero Bonds and Homogeneous Hydrogenation
(2018-07-18)
Chapter 1: Metal carbenoids in organic synthesis
The chapter describes the phenomena of metal carbenoid insertion reactions in two parts: Part A, and Part B. The study of N-tosylhydrazones as diazo precursor was commenced ...
Organocatalytic Cascade Cyclizations for the Enantioselective Synthesis of Spirooxindoles
(2018-06-18)
The thesis entitled “Organocatalytic Cascade Cyclizations for the Enantioselective Synthesis of Spirooxindoles” is divided into three chapters.
Chapter 1: Catalytic Enantioselective Michael Addition/Cyclization Cascade ...
The Role of Liposomal Hybrids and Gold Nanoparticles in the Efficacious Transport of Nucleic Acids and Small Molecular Drugs for Cancer Nanomedicine
(2018-07-23)
The thesis entitled “The Role of Liposomal Hybrids and Gold Nanoparticles in the Efficacious Transport of Nucleic Acids and Small Molecular Drugs for Cancer Nanomedicine” elucidates the preparation of various liposomal ...
Design and Synthesis of Peptidomimics Constrained in Helical and Sheet Conformations using a Novel Covalent Surrogate for the Peptide Main Chain Hydrogen Bond
(2018-07-20)
This thesis entitled “Design and Synthesis of Peptidomimics Constrained in Helical and Sheet Conformations Using a Novel Covalent Surrogate for the Peptide Main Chain Hydrogen Bond” is divided into six chapters.
Chapter ...
Alkynones Derived from Tartaric Acid : Efficient Building Blocks for the Synthesis of Macrolactone Natural Products
(2018-07-05)
The thesis describes the synthesis and application of various alkynones derived from the bis-Weinreb amide of tartaric acid in the total synthesis of macrolactone natural products. The thesis is divided into three sections. ...
Synthesis of Bivalent and Monovalent Sugar Ligands, their Interfacial and Solution Phase Lectin Bindng Studies
(2018-02-11)
Carbohydrate-protein interactions are responsible for several biological functions. While these interactions maintain high levels of specificities, the binding strength of individual carbohydrate-protein recognitions are ...