Browsing Organic Chemistry (OC) by Advisor "Jayaraman, Narayanaswamy"
Now showing items 1-18 of 18
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2,3-Dideoxy Sugars in Glycoconjugations and Cyclic Oligosaccharide Synthesis
2,3- Dideoxy sugars are versatile synthons for organic synthesis. The applications are diverse in biological systems and organic synthesis. In the first part of the thesis, 2,3-unsaturated sugars are used for the ... -
Allylic Halogenation Route to Latent-Active Trans-Glycosylation of Allyl Glycoside Donors
Allylic halogenation of allyl glycosides as a new route to allyl glycoside donors in glycosylations is investigated in this thesis. Allyl functionality is one of the commonly adopted protecting groups to hydroxyl groups ... -
Studies of Carbohydrate-Conjugated Anthracenes in Self-Assembly, Bioimaging and Photosensitization
Conjugation of a carbohydrate moiety to an aromatic core leads to glycostructures that possess a high propensity for self-assembly in aq. solutions, driven primarily by π-stacking of the aromatic ring, as well as, the ... -
Studies of Pyridoneimine in Site-Selective Functionalization of Carbohydrates and in Multivalent Phenomenon
Carbohydrates are functionally rich biomolecules with multiple hydroxy functionalities. As a result, the most often practiced chemical route is to install protecting groups that permit selective functionalization at the ... -
Studies On 2,3-Unsaturated Sugars : Reactivity Switching, Rearrangements And Conjugate Additions
(2015-12-21)Unsaturated sugars constitute as an important category of carbohydrate precursors in synthesis. Specifically, 1,2- and 2,3-unsaturated glycosides are excellent intermediates to derivatize monosaccharides and as building ... -
Synthesis and Studies of Covalent Polydiacetylene Glycopolymers as Scaffolds to Uncover Intricate Carbohydrate-Protein Interactions
Overall, the Thesis work establishes: • Monomeric and multimeric ligand-lectin interactions occurring at cell surfaces that could be assessed using purified protein and cellular model system, namely, glycovesicles; • ... -
Synthesis and Studies of Dendritic Poly (Ether Imine) Boronates and Cholesteryl-Functionalized Mesogens
(2018-07-31)Synthesis and Studies of Dendritic Poly(Ether Imine) Boronates and Cholesteryl-Functionalized Mesogens SYNOPSIS Dendrimers are hyperbranched synthetic macromolecules having branches-upon-branches structures, high molecular ... -
Synthesis And Studies Of Poly(Propyl Ether Imine) (PETIM) Dendrimers
(2010-10-14)Dendrimers are hyperbranched macromolecules, with branches-upon-branches architectures, precise constitutions and molecular weights of several kiloDaltons (Figure 1). The dendritic structure remains to be an influential ... -
Synthesis Of 2-Deoxy-1-Thioglycosides And Establishing Their Efficient Glycosyl Donor Properties To Prepare Aryl 2-Deoxy Glycosides And 2-Deoxy Oligosaccharides
(2010-07-08)Carbohydrates are a family of polyfunctional natural products and can be chemically modified in numerous ways. The primary significance of carbohydrates rests in their importance in biological functions. A particular class ... -
Synthesis of Bivalent and Monovalent Sugar Ligands, their Interfacial and Solution Phase Lectin Bindng Studies
(2018-02-11)Carbohydrate-protein interactions are responsible for several biological functions. While these interactions maintain high levels of specificities, the binding strength of individual carbohydrate-protein recognitions are ... -
Synthesis Of Septanosides Through An Oxyglycal Route And Studies Of Their Conformational And Mesophase Behavior
(2011-01-21)Cyclopropanes are strained molecules and undergo reactions, for example, through ring opening and rearrangements. Preparative methods and reactivities of cyclopropanes are known widely in organic synthesis. The high ... -
Synthesis, Conformation and Glycosidic Bond Stabilities of Septanoside Sugars
(2017-12-12)Seven-membered cyclic sugars, namely, septanoses and septanosides, are less commonly known sugar homologues. Synthesis of septanoses arise an interest due to their configurational and conformational features and the ... -
Synthesis, Conformational Analysis And Biophysical Studies Of Oligoarabinan And Oligoarabinomannan Glcolipids
(2013-07-19)Mycobacterial infection is a major health concern. High drug resistivity of the mycobacterium is due to its multi-layered, thick hydrophobic waxy cell wall components, consisting of cross-linked peptidoglycan (PG), mycolyl ... -
Synthetic Applications of C-2 Substituted Glucal
This report concerns the development of a synthetic approach towards synthesis of seven-membered septanosides, such as, substituted oxepanes from protected 2-hydroxyglycals. Important precursors to the synthesis of the ...