Inorganic and Physical Chemistry (IPC): Recent submissions
Now showing items 1-20 of 313
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Design and development of proteasome inhibitors with improved efficacy in breast cancer cells: 3D tissue models and detailed molecular mechanistic studies
The proteasome is an enzyme complex that regulates the degradation of intracellular proteins, maintaining cell cycle regulation, protein quality, and cellular homeostasis. Proteasome inhibition has gained popularity as a ... -
Genetic Code Expansion with Unnatural Amino Acids: Biosynthesis and Incorporation of Halogen and Chalcogen-containing Amino Acids into Proteins
Genetic code expansion (GCE) strategy allows incorporation of unnatural amino acids (UAAs) with diverse physical, chemical, and biochemical properties. Multiple UAAs have been successfully incorporated co-translationally ... -
Enzymatically Combating Biofilm Associated Microbial Infections: Towards Next-Gen Enzyme-Based Therapeutics
Bacteria employ various defense mechanisms, one of the most significant being forming biofilms─structured communities of microorganisms encased in a self-produced extracellular polymeric substance (EPS) matrix. The widespread ... -
Activation of H–E (E = H, Si, B, C) σ-Bond by Iridium and Rhodium Pincer Complexes: Implications in Catalytic (De)hydrogenation Reactions
Methane is a major constituent of natural gas and crude oil. Due to its abundance, methane is attractive from the standpoint of its utilization and conversion into value-added products.1 This process involves activation ... -
Studies on Solid State- and Photorechargeable- Batteries: From Interface Engineering to Material Design
Research work presented in the thesis involves fundamental studies on photorechargeable and solid-state energy storage devices. Lead-free perovskite (CsBi3I10) and a mixed chalcogenide (MoSeTe) based electrodes lead to ... -
Nano-engineering in Ionic Liquid: From Fundamentals to Advanced Catalysis
Harnessing nanostructured materials of metals has led to the development of various synthetic methodologies. Although various strategies have been developed, challenges still remain obtaining desired shape, size, and ... -
Redox Active Antioxidant Nanozymes as Potential Antithrombotic and Antiviral Agents
Reactive oxygen species (ROS), such as superoxide (O2-) hydrogen peroxide (H2O2), and hydroxyl radicals (.OH), generated as a result of cellular metabolism, play a multitude of physiological roles. They play key roles in ... -
Nitrite Releasing Molecules: Synthesis, Mechanism and Potential Application as Prodrugs for the Improvement of Nitric Oxide Bioavailability
The thesis titled “Nitrite Releasing Molecules: Synthesis, Mechanism and Potential Application as Prodrugs for the Improvement of Nitric Oxide Bioavailability“ aimed at the development of strategies for the improvement of ... -
Regioselective Di- and Tri-Fluoromethylative Difunctionalization of Olefinic Bonds Driven by Homolysis, Ionic and Single Electron Transfer Mechanisms
The transition metal free and additive free difunctionalization of carbon-carbon olefinic bonds through di-and tri-fluoromethylation serve as a potent method for simultaneously introducing two functional groups across ... -
Tuning Cellular Uptake of Small Molecules in Mammalian Cells by Substitution with Halogen and Chalcogen Atoms
Efficient cellular delivery of bioactive molecules is essential for the discovery and development of novel drugs. However, targeting intracellular proteins in the cytosol and other cellular components using small molecules ... -
Turning an Antioxidant into a Prooxidant: Light-induced Mitochondrial Apoptosis in Mammalian Cells by an Ergothioneine-based Neutral Small Molecule
Embargo up to Feb 28, 2026 Mitochondria-targeted compounds gained significant interest due to their applications in fundamental research, diagnostics, and therapeutics. In this work, we present a detailed investigation ... -
Single Molecular Break Junctions: Insights into Charge Transport and Chemical Reactivity
Molecular electronics leverages the unique quantum transport properties of single molecules or molecular assemblies to create nanoscale components with tailored functionalities. Constructing a detailed knowledge base of ... -
A Simple Scalable Route for the Production of Magnetic Nanomaterials and their Application in Wastewater Remediation
Superparamagnetic Iron Oxide Nanoparticles (SPIONs) have found extensive applications in diverse fields that include biomedicine, water remediation, and drug delivery. These applications require the development of synthetic ... -
Unravelling Delayed Luminescence Characteristics of Aminoboranes and Borylaniline: Fundamentals and Applications
The advancement of organic delayed luminescence (thermally activated delayed fluorescence (TADF) and room-temperature phosphorescence (RTP)) materials holds significant promise for applications in optoelectronics, bioimaging, ... -
Synthesis and Characterization of Cobalt-NHC Complexes: Application in Regioselective Hydroboration of Unsaturated Compounds
Boronic acid(esters) have been recognized as an indispensable coupling partner in several cross-coupling reactions, producing a vast spectrum of molecules applicable in diverse fields, from medicinal to materials sciences.[1] ... -
Oxygen Reduction Reaction on Copper Oxide Electrodes Doped with First-Row Transition Metals
The oxygen reduction reaction (ORR) is critical in electrochemical applications such as fuel cells, metal-air batteries, and industrial processes like chlor-alkali and H2O2 synthesis. Its universality lies in the fact that ... -
Host-Guest Chemistry of Water-Soluble Coordination Cages and their Applications
Host-guest interactions are key to enzyme-substrate recognition, where the enzyme acts as a host, providing a specific cavity for the guest to bind. Inspired by host-guest interactions observed in nature, a significant ... -
Design and Development of Hybrid Catalyst for Hydrogen Storage: A Demonstrative Concept using Liquid Organic Hydrogen Carriers (LOHCs)
The urgent need to address CO2 emissions resulting from the industrial revolution has placed a strong emphasis on the reduction of greenhouse gases. As a result, hydrogen has gained significant attention as a sustainable ... -
Itaconate Based Dual-reactive Polymeric Coatings and Photo-cross-stitching Studies of Periodically Grafted Amphiphilic Systems
Dual-reactive coatings are those that covalently anchor to the substrate while at the same time permit installation of desired segments in a post-coating step; several approaches have been developed to design such polymers ... -
Water-Soluble Interlocked and Non-Interlocked Architectures for Applications in Chemical Reactions and Molecular Separation
Molecular recognition plays a crucial role in many natural processes, such as substrate binding to receptor proteins, antigen–antibody interactions, signal induction by neurotransmitters, and cellular recognition. This ...