Division of Biological Sciences: Recent submissions
Now showing items 81-100 of 1085
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Decoding of Attention and Behavioral State Using Local Field Potentials
Visual attention has been shown to modulate perceptual behavior and neuronal activity. Early psychophysical studies on attention showed that the subjects detected a target presented at the attended location better (i.e., ... -
Algorithms for Investigating, Decoding and Designing ligand recognition sites in proteins - A Structural Bioinformatics Approach to Studying Protein Function
All physical processes in living organisms are driven by specific biomolecular interactions. Elucidating the characteristics of biomolecular interactions between proteins and their respective small molecule ligands can ... -
Understanding the role of DNAJC30 and ISCU in mitochondrial homeostasis
Williams-Beuren Syndrome (WBS) is a rare multisystem genomic disorder characterized by mild to moderate cognitive impairment, unique personality traits, distinctive facial features, cardiovascular problems, and infantile ... -
On mechanisms and conformational dynamics of Drug:H+ Antiporters
Multidrug efflux is an active transport process involving energy consumption to drive antibacterial compounds out of cells. This is performed either through primary active transport, where chemical energy, such as hydrolysis ... -
Translation in the 3'Untranslated Region of Mammalian Transcripts
Mammalian mRNAs generally have a 5'UTR (untranslated region), a coding DNA sequence, and a 3'UTR. The 3'UTR of mRNA is generally believed to be the untranslated region of the mRNA. However, there are certain instances ... -
Role of 3D-organization of the X-inactivation centre in imprinted X-chromosome inactivation
The connection between 3D-genome organization and genome regulation is one of the fundamental questions in modern biology. In a nucleus, the genome is organized through different layers of 3D-organization such as ... -
The Nse1p RING domain is required for maintaining transcriptional silencing and genomic organization in Saccharomyces cerevisiae
Chromatin is a dynamic structure that reorganizes to support proper transcription, replication, repair, and segregation. Principal chromosomal constituents that shape chromosomes are the SMC (Structural Maintenance of ... -
miRNA-based regulation of Coxsackievirus B3 replication and pathogenesis
Coxsackievirus B3 (CVB3) is a single-stranded, positive-sense RNA virus known to cause acute myocarditis, pancreatitis, and aseptic meningitis. In many cases, the long-term impact of CVB3 infection-induced cell death ... -
Characterization of Visual Stimulus-Induced Gamma Oscillations as Signatures of Mechanisms Underlying Healthy Aging and Disease
Neural oscillations are rhythmic fluctuations in the electrical activity recorded from the brain that convey important information about brain function. Gamma oscillations, which refer to the 30–80 Hz frequency range, are ... -
Peritoneal colonization of ovarian cancer
The primary cause of mortality associated with cancer is metastasis, i.e., the spread of transformed cells from the site of oncogenesis to secondary loci within the body. Epithelial ovarian cancer (EOC) is a debilitating ... -
Translation in Erythroid cells
Erythrocytes are specialized cells that perform the crucial function of gas exchange in all vertebrates. Regulation of gene expression was believed to be absent in these cells due to the absence of nucleus. It was also ... -
Qualitative similarities and differences between monkey and human visual perception
Animal models play a crucial role in helping neuroscientists unravel the computations supporting behaviour at the resolution of a single neuron in the brain. In vision science, the macaque monkey is the pre-eminent model ... -
Functional characterisation of splicing factor Slu7 in Cryptococcus neoformans – roles in cell cycle, constitutive and alternate splicing
Fungal genomes, including in pathogenic yeasts like Cryptococcus neoformans (Cnn) and Candida albicans are rich with short introns. 99% of Cryptococcus neoformans genes have introns with an average of 5 introns per gene ... -
Structure-function and evolution of a unique uracil DNA glycosylase, UdgX, from Mycobacterium smegmatis
Mycobacterium smegmatis, a soil bacterium, faces multiple challenges in its environment, including exposure to reactive oxygen species (ROS), reactive nitrogen intermediates (RNI), radiation, and various other chemical ... -
Understanding the adaptive responses of Salmonella Typhimurium during bile stress
Salmonella Typhimurium (S. Typhimurium) is an enteric pathogen that causes gastroenteritis. Although gastroenteritis is usually non-life threatening in healthy adults, it can cause fatality in children and immunocompromised ... -
Studying the role of small GTPase Rab14 in the regulation of endosomal function
The endomembrane system and their associated membrane trafficking are fundamental features of eukaryotic cell biology. These processes are regulated by small GTP-binding proteins that acts as molecular switches to ... -
Establishment of a knock-in mouse model expressing a hypomorphic variant of receptor guanylyl cyclase C
Receptor guanylyl cyclase C (GC-C, gene GUCY2C) is expressed on the apical surface of the intestinal epithelial cells and gets activated by the endogenous ligands guanylin and uroguanylin. Heat-stable enterotoxin (ST) ... -
Deciphering the biochemical and biophysical properties of the Holliday junction resolvases RuvC and RuvX from Mycobacterium smegmatis
Homologous recombination (HR) is a ubiquitous cellular process that occurs in all three domains of life as well as in DNA and RNA viruses. In eukaryotes, HR is critically important for homology-directed DNA repair (HDDR) ... -
Astrocytes regulate oligodendrocyte development and myelination in the mammalian brain
Oligodendrocytes (OLs), a type of glial cell, are the main myelinating cells of the mammalian central nervous system (CNS), enabling efficient saltatory mode of nerve conduction. On the other hand, astrocytes, another glial ... -
Insights into life-cycle stage transition of Trichomonas vaginalis and advancement in its diagnosis
Trichomonas vaginalis is a protozoan parasite and the causative agent of the most common non-viral, sexually transmitted disease (STD) in humans known as trichomoniasis. WHO estimates more than 270 million cases of ...