Division of Biological Sciences: Recent submissions
Now showing items 61-80 of 1176
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Molecular dissection of Komagataella phaffii Rtg1–RtgX function and development of a glutamate-responsive protein expression platform
In Saccharomyces cerevisiae, the basic helix-loop-helix leucine zipper (bHLH-LZ) proteins Rtg1 and Rtg3 form a heterodimeric transcription factor complex that mediates the retrograde response. In Candida albicans, these ... -
Studying induced and evoked oscillations for probing visual and auditory circuit mechanisms
Specialized sensory regions process incoming sensory inputs using a variety of mechanisms, such as normalization and excitatory-inhibitory interactions. These mechanisms can be studied through induced and evoked oscillations, ... -
Circuit mechanisms of itch modulation: from physiology to pathology
Itch is a distinct somatosensation, evoked by chemical and mechanical pruritogens or psychosomatic factors. It detects harmful sensory stimuli and triggers scratching to remove irritants from the skin. However, chronic ... -
Biomechanical and biochemical regulation by the extracellular matrix of breast cancer migration
Although under active investigation, alterations within the microenvironment that are causative to, and a consequence of, tumor progression are only beginning to be better appreciated through advances in imaging, experimental, ... -
Role of PARP16 in Cardiac Remodeling
Role of PARP16 in cardiac remodeling Cardiac remodeling, a complex process involving alterations in myocardial structure and function, is a major contributor to heart failure. While physiological remodeling supports cardiac ... -
Regulation of the Expression of Ribosomal Proteins by Small Downstream ORFs
Eukaryotic mRNAs have historically been believed to harbour a single open reading frame (ORF). However, over the last decade, ribosome profiling has revealed extensive ribosome occupancy in the untranslated regions ... -
An expedition through local and global features of intrinsically disordered proteins using computational lenses
The traditional view in Structural Biology centered on the “one sequence–one structure–one function” paradigm, which emphasized a unique, folded state of protein as the basis for its biological activity. However, this ... -
Mechanistic insights into the recruitment of viral type 2 IRES to ribosomal pre-initiation complex and its interaction with eIF4 factors and PTB1
Viruses often employ internal ribosome entry sites (IRESs) in their genomic RNA to hijack the host’s translational machinery. The IRES elements are characterized by unique secondary and tertiary RNA structures capable of ... -
Achieving oral bioavailability of therapeutic macrocyclic peptides by bridging backbone chemistry with pharmacokinetics
Full text embargo up to Dec 11, 2026 Macrocyclic peptides are emerging as very potential candidates for drug development. Due to the advancement in display technologies, macrocycles can target undruggable proteins. These ... -
Understanding the molecular mechanisms of redox-dependent mitochondrial homeostasis mediated by DJ-1 paralogs in Saccharomyces cerevisiae
Mitochondrial integrity is a crucial determinant of overall cellular health. Mitochondrial dysfunction and impediments in regulating organellar homeostasis contribute majorly to the pathophysiological manifestation of ... -
Design of viral entry inhibitors and vaccines
Full text Embargo upto 12/12/2026 Human Immunodeficiency Virus type 1 (HIV-1) remains one of the most persistent global health threats, despite significant efforts in the development of vaccines and major strides in ... -
Theoretical investigation on the geminal proton-carnon-13 Coupling constants
It has been concluded from the present study that the geminal proton coupling of carboxyl (carbonyl) carbon-13 has an angular dependence of the form: A+Bcos?2?A + B \cos^2 \thetaA+Bcos2? based on the relative orientation ... -
Elucidating the TSC2-mediated transcriptional regulation of miR-514b-3p
The PI3K-AKT-MTOR signalling axis is pivotal in regulating cell survival, proliferation, and growth. Tuberous sclerosis complex (TSC) is a well-established negative regulator of this pathway, which primarily acts by ... -
Influence of population bottlenecks on the evolution of sociality in synthetic life-cycle
Cooperation requires individuals to invest their resources for the benefit of others. Cooperative behaviours often involve the secretion of costly public goods, which can be exploited by spontaneous mutant cheater cells ... -
Tuning the Circuit, Steering the Swarm: CASY-1 in Synaptic and Behavioral Modulation
Disruptions in neuromodulatory signaling are a hallmark of several neurodevelopmental and psychiatric disorders. However, the molecular mechanisms that fine-tune neuromodulation across circuits and behaviors remain poorly ... -
Epigenetic repression of stemness genes by the TCP/KNOX-II transcription factors in simple leaf development of Arabidopsis
Leaves are initiated as primordia at the flanks of the shoot apical meristem. Primordia in the simple-leaved species such as Arabidopsis produce single lamina, whereas those in compound-leaved species such as tomato ... -
Understanding the Mechanism of DNA Double-Strand Break (DSB) Repair in Mitochondria and Various Mammalian Organs.
Various exogenous and endogenous agents can damage DNA. Exogenous agents include chemicals and radiation, such as ionizing radiations and UV rays, while endogenous agents include DNA replication errors, reactive oxygen ... -
Deciphering the role of miR-631 in the pathogenesis of oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) is a malignant neoplasm originating from the epithelial cells of the oral cavity. The Asian population has the highest incidence of OSCC and despite advances in its treatment, the five-year ... -
Immunogen design to enhance Influenza and SARS-CoV-2 vaccine efficacy
Influenza and SARS-CoV-2 are pleomorphic viruses that cause respiratory diseases in humans and present significant public health threats. Vaccination has been essential in controlling the spread of these infections and ...