Division of Biological Sciences: Recent submissions
Now showing items 41-60 of 1186
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Bacterial transformation of nitroaromatic compounds and its implicatins in detoxification
Nitroaromatic compounds form a major group of environmental pollutants because of their high toxicity, widespread use, and recalcitrance to microbial degradation. The studies incorporated in this thesis aimed at understanding ... -
Effect of 2-methyl-4-dimethly aminoazobenzene on mithchondrial function and turnover
Abstract not available -
Metabolism of phenolic acids in relation to the biosynthesis of ubiquinone and sterols
Abstract not available -
Structural and mechanistic studies on RNase J paralogs and associated multi-enzyme complexes in Staphylococcus aureus
The Staphylococcus aureus RNome, which includes both coding and non-coding RNAs, has a direct bearing on the virulence of this pathogen as it influences the ability to adapt to diverse environments within the host. Multiple ... -
Conformational and Dynamic Motifs in the Biomolecular Recognition of Glycan and Acetyl Functionalities
Biomolecular recognition is a fundamental principle underlying all cellular processes, driven by specific and tightly regulated interactions. This thesis explores the structural basis of recognition mechanisms in two ... -
Physiological Significance of Stop Codon Readthrough
Regulation of translation, the process by which ribosomes synthesize proteins from mRNAs, is critical to maintain cellular proteostasis. Dysregulation of translation is implicated in several neurodegenerative, metabolic, ... -
Lectin from mimosa invisa L and its role in rhizobium recognition
Understanding the specificity of the legume-Rhizobium symbiosis may help in improving biological nitrogen fixation in several ways. The causes for this specificity have been studied in only a few systems like clover, ... -
Studies on the mode of inhibition of avian myeloblastosis virus multipulication by cupric isonicotinic acid hydrazide complex
The primary objectives of cancer chemotherapy programs include the screening and evaluation of new chemicals and natural products in experimental systems for their anticancer activity and the recommendation of new anticancer ... -
Conformational studies on polynuc leotides and nucleic acids
After an introduction to the nucleic acids and the conformational studies on them at the monomeric and polymeric levels, the need for investigations on the conformations of 3?-nucleotides is outlined. The significance of ... -
Studies on O-H-O Hydrogen Bonds and conformation of cyclic hexa depsipeptides
The working criteria which have been developed for both O-H...O and N-H...O types of hydrogen bond can be utilised. FIG. 3.5. FLOW CHART OF THE PROGRAM MODULE Read input data: (a) coordinates of the hydrogen bond forming ... -
Motifs in proteins: Disulfide constraints and their applications to protein engineering and peptide modelling
By carrying out a detailed data analysis of 175 PP motifs in proteins, sequence–structure relationships were identified for linking loops 1–5 residues long. Conformational families were recognized in 1-, 2-, 3-, and 4-residue ... -
X-ray crystallagraphic studies on the effect of chirality in amino acids aggregation
A programme of systematic X-ray studies on crystalline complexes involving amino acids and peptides is currently under way in this laboratory. These studies, apart from providing a wealth of information on non-covalent ... -
Theoretical studies on peptide conformation
It is now well established that the biological activities of polypeptides and proteins are intimately connected with their 3-dimensional structures and so the determinations of these provide insight into their mode of ... -
Theoretical studies on the influence of exo-anomeric effect,geometry of sugar linkage on the unperturbed dimensions of polysaccharides
Recently, application of conformational energy calculations in the field of carbohydrates has led to a number of interesting and important results. A few attempts have also been made to compute the unperturbed dimensions ... -
Enhancing Therapeutic Potential of Antimicrobial Peptides by Tuning Backbone Conformation
Full text embargo up to Dec 31, 2026 The work reported in this thesis involves tuning the backbone conformation of b-hairpin AMPs to reduce their cytotoxicity, which is determined in terms of reduced hemolytic activity, ... -
Control and Co-ordination in Multi-Joint Movements
Our interactions with the world often entail a wide range of multi-jointed movements. We are bestowed with an abundant degree of freedom, that a movement can be achieved by recruiting multiple joints, muscles, and neural ... -
Behavioural and neural signatures of interactions between conflicting emotion and reward
Reward-related events seldom occur in isolation in our everyday lives — a component of emotion processing remains intertwined in many cases. For instance, individuals often work under hostile conditions for higher pay or ...