Division of Biological Sciences: Recent submissions
Now showing items 101-120 of 1060
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Flavivirus RNA replication: Probe development, structural dynamics, and role of zinc ions.
Flaviviruses share a typical genome architecture where the highly conserved UTRs flank a central coding region. They also share a common genome replication strategy called genome cyclization where the UTRs interact to form ... -
Dissecting the function of NuMA in cleavage furrow formation and chromatin decondensation at the mitotic exit in animal cells
In animal cells, the duplicated genetic material is aligned on a microtubule-based structure known as the mitotic spindle during mitosis. At the mitotic exit, the mitotic spindle elongates, and the sister chromatids get ... -
Parietal and prefrontal control of distinct components of attention
In this thesis, we investigate behavioural mechanisms and neural substrates of distinct components of endogenous spatial attention. Endogenous attention facilitates neural processing of the selected stimulus through one ... -
Systems biology approach to dissect Salmonella-host interactions
Systems understanding of the biological data is required to capture the complex biochemical information when a pathogen interacts with its host. Such interactions are dynamic and complex, especially because various components ... -
Studies on the promoter specificity determinants and modulators of the prokaryotic transcription machinery
Bacteria adapt to a wide range of environmental conditions by synchronizing transcription with changes in the extracellular environment. This is achieved by the synchronized action of two-component systems, Extra Cytoplasmic ... -
Development of 3D model and understanding translational regulation of breast cancer
Breast cancer is the most common cancer among women in India and worldwide. It is a highly heterogeneous disease caused by several genetic and epigenetic alterations in mammary epithelial cells. Both inter- and intra-patient ... -
Role of Sirt2 in Stress-induced Muscle Atrophy
Skeletal muscle is one of the essential organs in our body, responsible for various functions such as locomotion, transport, protein storage, and thermoregulation. Under certain pathological conditions, there is a reduction ... -
Investigation of anticancer compounds in the natural productome of marine algae associated-endophytic fungi
Cancer is one of the leading causes of death worldwide. Owing to the complex ways in which this disease develops, there is a constant demand for new drugs. Natural products have delivered great promise in inspiring ... -
Differential Regulation of Calcium Dependent Phase Separation and Modular Assembly of Sap97/Hdlg Enriched Molecular Complexes
Recent studies over a few decades have changed the perspective of the molecular architecture of functional zones within synapses and other cell junctions. Observations in the last decade confirm Post Synaptic Density as ... -
Biochemical and structural studies to provide insights into initiator tRNA delivery by eIF2A in noncanonical translation initiation
Eukaryotic initiation factor 2A (eIF2A), a non-canonical translation initiation factor, delivers initiator tRNA (tRNAi) onto the 40S ribosomal subunit in a codon-dependent and GTP-independent manner, unlike the canonical ... -
Epigenetic modulation of Foam cell generation during Mycobacterium tuberculosis/ Cryptococcus neoformans infection
Foamy macrophages or Foam cells are a critical cellular component of the granuloma formed during pulmonary infection. These lipid rich cells generally contain neutral lipids, Cholesteryl Esters (CE) and/or Triglycerides ... -
Metabolic Regulation of Gametocytogenesis in Malaria
Plasmodium sp. is an obligate intracellular protozoan parasite causing malaria and is responsible for more than 500,000 human deaths annually. P. falciparum and P. vivax are the two major species causing malaria in humans. ... -
Solution structures and interaction studies of mycobacterial MazEF6 toxin-antitoxin system
Toxin-Antitoxin (TA) systems are stress response systems found on plasmids and chromosomes of bacteria and archaea. They are involved in important functions such as plasmid maintenance, programmed cell death, persister ... -
Deciphering the role of outer membrane porins in the pathogenesis of Salmonella enterica serovar Typhimurium
Porins are highly conserved barrel-shaped proteins bound to the bacterial outer membrane and involved in the selective transport of charged molecules across the membrane. They consist of parallel and anti-parallel β sheets ... -
Effect of Stimulus Normalization and Visual Attention at multiple scales of Neural Integration
The effect of visual attention on neural signals has been extensively studied using various techniques such as macaque neurophysiology and human electro/magneto encephalogram (EEG/MEG). Depending on the technique, different ... -
Substrate interrogation of the CRISPR-Cas12a endonuclease reveals an unexpected functional plasticity
Substrate interrogation of the CRISPR-Cas12a endonuclease reveals an unexpected functional plasticity Currently, Cas9 and Cas12a (also known as Cpf1) are the sole members of a large family of RNA-guided nucleases that ... -
A study of extracellular matrix dynamics in epithelial cancer progression with a special focus on ovarian cancer spheroidogenesis
Epithelial ovarian cancer (EOC) is one of the most debilitating gynecological cancers in women worldwide due to its insidious symptoms. The predominant subtype of ovarian cancer: high-grade serous ovarian carcinoma (HGSOC), ... -
Exploring the role of low complexity protein sequence in regulating RNA granule dynamics and translation control
RNA granules are conserved membraneless mRNP complexes that play an important role in determining mRNA fate by affecting translation repression and mRNA decay. Processing bodies (P-bodies) harbor enzymes responsible for ... -
Understanding the role of mtHsp70 in regulating mitochondrial homeostasis: revealing its significance in Congenital Sideroblastic Anemia progression
Mitochondria are ubiquitous organelles placed at the nexus of several metabolic and signaling pathways essential for cell survival. Therefore, maintaining a healthy and functional organelle becomes paramount for the cell. ... -
Unraveling the multifaceted interactions between the tumor cell hierarchy and the stroma: Implications on tumor growth
In this study, we have functionally characterized the roles of SEZ6, a GSC-specific protein, and FMOD, a DGC-specific protein, in inducing tumor angiogenesis. Angiogenesis being a crucial requirement for both tumor initiation ...