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Characterization of Visual Stimulus-Induced Gamma Oscillations as Signatures of Mechanisms Underlying Healthy Aging and Disease
Neural oscillations are rhythmic fluctuations in the electrical activity recorded from the brain that convey important information about brain function. Gamma oscillations, which refer to the 30–80 Hz frequency range, are ...
Peritoneal colonization of ovarian cancer
The primary cause of mortality associated with cancer is metastasis, i.e., the spread of transformed cells from the site of oncogenesis to secondary loci within the body. Epithelial ovarian cancer (EOC) is a debilitating ...
Translation in Erythroid cells
Erythrocytes are specialized cells that perform the crucial function of gas exchange in all
vertebrates. Regulation of gene expression was believed to be absent in these cells due
to the absence of nucleus. It was also ...
In vivo mechanistic insights into the trans-splicing based expression of Hsp90 in Giardia lamblia
Giardia lamblia, a simple yet intriguing protozoan parasite, challenges conventional paradigms in gene expression through its unique mechanism of trans-splicing for Heat Shock Protein 90 (Hsp90). As a primitive organism, ...
Understanding structure, function, and dynamics in macromolecular complexes
In the scope of my thesis work, a concerted effort was undertaken to elucidate bi-
ological functions through the lens of structural analysis, employing protein dy-
namics. The role of protein dynamics in shaping and ...
miRNA-based regulation of Coxsackievirus B3 replication and pathogenesis
Coxsackievirus B3 (CVB3) is a single-stranded, positive-sense RNA virus known to cause
acute myocarditis, pancreatitis, and aseptic meningitis. In many cases, the long-term impact of
CVB3 infection-induced cell death ...
Role of 3D-organization of the X-inactivation centre in imprinted X-chromosome inactivation
The connection between 3D-genome organization and genome regulation is one of the fundamental questions in modern biology. In a nucleus, the genome is organized through different layers of 3D-organization such as ...
Translation in the 3'Untranslated Region of Mammalian Transcripts
Mammalian mRNAs generally have a 5'UTR (untranslated region), a coding DNA
sequence, and a 3'UTR. The 3'UTR of mRNA is generally believed to be the
untranslated region of the mRNA. However, there are certain instances ...
Conformational Heterogeneity, Solution Structure and Autoregulatory Roles of the MazE9 Antitoxin from Mycobacterium tuberculosis
The work presented in this thesis endeavors to decode the details of the dynamics of MazE9 antitoxin of the Mycobacterium tuberculosis MazEF9 toxin-antitoxin system and the transcriptional autoregulation effected by it. ...
Exploring the Marine Algicolous Endophytic Fungi: A Promising Source of Novel Cancer Therapeutics
Cancer is the second leading cause of mortality globally, with over 6 million new cases diagnosed annually. Research on effective therapies is crucial due to the disease's complexity. Natural materials in chemotherapy have ...