Browsing by Title
Now showing items 2816-2835 of 6415
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Investigating the redox signaling mechanisms during HIV-TB co-infection
Oxidative stress has been at the forefront of HIV/AIDS-related pathophysiologies since the early days of its discovery. Overcoming HIV-1 latency, wherein, the virus remains integrated in the host chromatin, undetected and ... -
Investigating the role and regulation of Polypyrimidine tract binding protein (PTB) in isoform switching during muscle development in Drosophila melanogaster
Muscles are an excellent system to dissect the development, physiology and evolution of cell heterogeneity and isoform switching. The vertebrate skeletal muscles are composed of heterogeneous muscle fibres. These fibres ... -
Investigating the role of AMPK in mammary gland alveologenesis and lactation
AMP-activated kinase (AMPK) is an energy sensor that regulates cell growth and metabolism. Reports from our laboratory and others have shown the context-specific role of AMPK signaling in breast cancer. However, its role ... -
Investigating the role of an atypical dual-specificity phosphatase DUSP28 in mammalian cells
Dual-specificity phosphatases (DUSPs) belong to the protein tyrosine phosphatases (PTP) subfamily and dephosphorylate, both serine/threonine and tyrosine residues of proteins and non-protein substrates. A subgroup of ... -
Investigating the Role of Domain Swapping in Aggregation of Globular Proteins
The broad objective of this thesis involves computationally modeling protein aggregation with special emphasis on the role of cosolvents and misfolded states. Chapter 1 contrasts the effect of biologically relevant co-solvents ... -
Investigating the role of mantle convection in affecting surface deformation and topography in the Indian plate and the India-Eurasia collision zone
The India-Eurasia collision zone has been a subject of various studies that have tried to explain the forces behind the high elevation and large scale continental deformation in this region. However, the relative contribution ... -
Investigating the role of miR-198 in oral squamous cell carcinoma pathogenesis
Evidence supports the critical role of microRNA (miRNA) dysregulation in several diseases including cancers. The aberrant expression of numerous tumor suppressor and oncogenic miRNAs is a well-established driving factor ... -
Investigating the role of taxi gene in flight behavior of Drosophila melanogaster
Locomotion is essential for animals and it is regulated by crosstalk between neurons and muscles. Although defects in the crosstalk between neurons and muscles are implicated in many mobility related diseases in human, ... -
An Investigation into the Ancillaries, Parallel Operation of Machines with Voltage Source Inverters, and Development of Switched Capacitor Converters for a Microgrid
With the increase in energy demand worldwide, there is a push towards integrating distributed generation (DG) in parallel with the utility grid at the distribution level. The DGs are integrated into the electrical network ... -
An investigation into the axial dipole field and mantle-induced heterogeneity in Earth
The Earth’s axial dipole field is generated by dynamo action in the planet’s outer core. It is understood from observations that the convection in the outer core is influenced by the lateral heterogeneity in the overlying ... -
Investigation into the Synthesis, Structure and Dielectric Property of Lead-Free Double Perovskite Structured Materials
Lead based materials have shown to be important materials showing high piezoelectricity, colossal dielectric constant, ferroelectricity along with their good mechanical behaviour and resistance to corrosion. As a result, ... -
Investigation of 1D nanostructures and heterostructures using electron microscopy
Inorganic colloidal nanocrystals are extensively used in various fields such as electronics, sensing, photonics, thermoelectrics and catalysis. The intriguing properties of these colloidal nanocrystals can be attributed ... -
Investigation Of A Novel Class Of Conducting Polyaniline And Related Systems
(2007-10-25)The interest in conjugated polymers has been two-fold. A rich variety of intriguing physical phenomena, combined with its immense technological implications in the area of molecular electronics, sensors etc. has inspired ... -
Investigation Of Aerosol Characteristics Over Inland, Coastal And Island Locations In India
(2011-02-10)This thesis is based on measurements of aerosol optical and microphysical properties made at inland, coastal and island locations in India. Aerosol vertical distribution measurements have also been made both using surface ... -
Investigation of an Axisymmetric Spiked Body in a Hypersonic Shock Tunnel
The forefront research in the regime of hypersonic flow is intended to focus on improving the overall performance of the existing aerospace vehicles. A high-speed vehicle experiences a high level of aerodynamic heating and ... -
Investigation of anticancer compounds in the natural productome of marine algae associated-endophytic fungi
Cancer is one of the leading causes of death worldwide. Owing to the complex ways in which this disease develops, there is a constant demand for new drugs. Natural products have delivered great promise in inspiring ... -
An Investigation of Architectures For Integration Of Stand-Alone INS And GPS Navigation Systems
(2009-07-08)Inertial navigation systems (INSs) have the well-known advantages of being self-contained, weatherproof, jam-proof, and non-self-revealing while providing stable navigation information with little high-frequency noise. ... -
Investigation of Au-free AlGaN/GaN HEMT on Silicon with substrate transfer process: From Ohmic contacts to RF performance
The technological importance of III-nitride based high electron mobility transistors (HEMTs) for power switching and RF applications is growing rapidly, owing to two advantageous electrical properties. While high sheet ... -
Investigation of Buffer Design and Carbon doping in AlGaN/GaN HEMTs for High Breakdown Voltages
III-nitride HEMTs are strong contenders for next-generation power electronic applications. The superior material and electrical properties render GaN-based transistors suitable for high-power switching. The material ... -
Investigation of cell membrane dynamics: A potential marker for lipid response towards membrane-active proteins and peptides
The cell membrane is made up of lipids and proteins held together with intermolecular hydrophobic/hydrophilic interactions. These physical non-covalent interactions help in maintaining the integrity of the cell membrane, ...