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Now showing items 1033-1052 of 8778
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Conformation of peptidoglycan and mode of penicillin action
Penicillins and cephalosporins are conformationally similar to D-L-Ala-D-Ala due to the presence of the lactam ring. The mode of binding of the aminoacyl group of penicillin and cephalosporin with transpeptidase is the ... -
CONFORMATION OF POLYNUCLEOTIDES
The conformations of the five?membered rings and other relevant conformational features of deoxyribose, ribose, and arabinose have been analysed in this chapter and in the preceding two chapters. The analysis included ... -
Conformational Analysis And Design Of Disulfides In Antiparallel β-Sheets And Helices
(2013-08-30)Disulfides are the primary covalent interactions within a protein molecule that connect residues which are sequentially distant. Naturally occurring disulfides enhance the stability of the protein by destabilization of ... -
Conformational analysis of cyclic peptides containing Cis peptide units
The dimensions of the cis peptide unit obtained as an average from the three sets of data viz., cyclic di-, higher, and tripeptides are summarized in Table 2.11. On a close examination of the Table, the following salient ... -
Conformational Analysis Of Designed Alpha-Omega Hybrid Peptides
(2011-10-21)The insertion of ω- amino acid residues as guests into host α-peptide sequences permits expansion of the range of polypeptide secondary structures. The term ω- amino acid is used to refer to the entire family of residues ... -
Conformational Analysis of Designed and Natural Peptides : Studies of Aromatic/Aromatic and Aromatic/Proline Interactions by NMR
(2018-04-05)This thesis describes NMR studies which probe weak interactions between amino acid side chains in folded peptide structures. Aromatic/aromatic interactions between facing phenylalanine residues have been probed in antiparallel ... -
Conformational and Dynamic Motifs in the Biomolecular Recognition of Glycan and Acetyl Functionalities
Biomolecular recognition is a fundamental principle underlying all cellular processes, driven by specific and tightly regulated interactions. This thesis explores the structural basis of recognition mechanisms in two ... -
Conformational Heterogeneity, Solution Structure and Autoregulatory Roles of the MazE9 Antitoxin from Mycobacterium tuberculosis
The work presented in this thesis endeavors to decode the details of the dynamics of MazE9 antitoxin of the Mycobacterium tuberculosis MazEF9 toxin-antitoxin system and the transcriptional autoregulation effected by it. ... -
Conformational Reorganization Of Hyperbranched And Linear Polymers And Functionalized Porous Polymer Films
(2014-04-22)The main focus of the research work presented in the thesis is the understanding of structural and conformational reorganizations in hyperbranched and linear polymers. The thesis includes three different investigations: ... -
conformational studies on hydrogen bonded cyclic hexapeptides
In the first place, the uniqueness of any MEC within a certain region demonstrates the successful incorporation of the hydrogen?bond energy function in a minimization program. In particular, its interpolation with the ... -
Conformational studies on peptides containing alpha aminoisobutyric acid and polypeptides with alternating LD-Sequences
The results of semiempirical energy calculations on poly(Aib), varying ACO and ?(NC?C) separately and simultaneously, suggest a novel fourfold helical structure as an energetically favourable model for poly(Aib). This novel ... -
Conformational studies on polynuc leotides and nucleic acids
After an introduction to the nucleic acids and the conformational studies on them at the monomeric and polymeric levels, the need for investigations on the conformations of 3?-nucleotides is outlined. The significance of ... -
Conformationalflexibility of DNA: Polymorphism and handness
Observation of both right- and left-helical DNA fragments in the single crystals and different poly morphous forms of DNA in fibres suggest that the con formational flexibility is inherent in the DNA mole cule. However, ... -
Confronting realistic MHD simulations of solar eruptions with observed space based data
Solar flares and Coronal Mass Ejections (CMEs) are among the most violent and energetic phenomena observed in the solar atmosphere, resulting from the sudden release of immense amounts of energy. A typical solar flare is ... -
Conjugate Natural Convection In Horizontal Annuli
(2011-06-23) -
Conjunctive And Multipurpose Operation Of Reservoirs Using Genetic Algorithms
(Indian Institute of Science, 2006-07-17)Optimal operation of reservoir systems is necessary for better utilizing the limited water resources and to justify the high capital investments associated with reservoir projects. However, finding optimal policies for ... -
Conservation and divergence of the nucleotide excision repair pathway: Comparison of UvrB and UvrC proteins from Mycobacterium tuberculosis and Escherichia coli reveal significant differences in their functional properties
This thesis is presented in three chapters divided by topics. Chapter I will begin with an overview of literature regarding different types of DNA damage, DNA repair pathways in bacteria, properties of E. coli UvrABC ...