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Now showing items 31-40 of 52
Protein Engineering of HIV-1 Env and Human CD4
(2018-05-01)
Since, its discovery over three decades ago, HIV has wrecked havoc worldwide. According to the UNAIDS report 2011, at present 34 million people is living with HIV and AIDS vaccine with broadly neutralizing activity still ...
Structural Studies on Heat Shock Protein 90 from Dictyostelium Discoideum and Oryza Sativa
(2018-05-09)
Molecular chaperones are proteins that interact with and aid in stabilization and activation of other proteins. Chaperones help proteins attain their three dimensional conformation, without forming a part of the final ...
Protein Engineering and Stabilization of HIV-1 Envelope Glycoprotein
(2018-05-09)
A number of viral diseases such as Hepatitis B, small pox, measles, rubella and polio have effective vaccines to control or eradicate them. HIV-1 is a lentivirus which infects human immune cells and leads to the disease ...
Structural Studies on the Role of Hinge involved in Domain Swapping in Salmonella Typhimurium Stationary Phase Survival Protein (SurE) and Sesbania Mosaic Virus Coat Protein
(2018-05-09)
A unique mechanism of protein oligomerization is domain swapping. It is a feature found in some proteins wherein a dimer or a higher oligomer is formed by the exchange of identical structural segments between protomers. ...
Small Heat Shock Proteins from Oryza Sativa and Salmonella Enterica
(2018-05-09)
Small heat shock proteins (sHSPs) are a ubiquitous family of molecular chaperones that play a vital role in maintaining protein homeostasis in cells. They are the first line of defence against the detrimental effects of ...
Structural and Related Studies on Mycobacterial Lectins
(2018-05-09)
This thesis is concerned with the first ever X-ray crystallographic and complimentary solution studies on mycobacterial lectins. Lectins, described as multivalent carbohydrate binding proteins of non-immune origin, are ...
Molecular Characterization of Bacillus Subtilis Oxidoreductases involved in the Bacilysin Synthesis
(2018-05-11)
The biosynthetic pathway for the production of the dipeptide antibiotic bacilysin has been the subject of intense research over the past three decades. These studies revealed the role of multiple enzymes in the biosynthesis ...
Biochemical, Biophysical and Evolutionary Perspectives of Zinc Finger Proteins in Mycobacterium smegmatis
(2018-05-21)
Transcription is a major step in expression of genes of a given organism. Due to environmental constrains this step must be regulated in the favour of the sustenance and growth of the organism. Here comes the relevance of ...
Design and Characterization of HIV-1 ENV Derived Immunogens
(2018-06-21)
The Human Immunodeficiency Virus (HIV) is a member of the retroviridae family from lentivirus genus which primarily infects CD4+ T cells and also to lesser degree monocytes, macrophages, and dendritic cells causing progressive ...
GABAA Receptor Mediated Phasic and Tonic Inhibition in Subicular Pyramidal Neurons
(2018-07-28)
GABA is the major inhibitory neurotransmitter in the central nervous system. It binds to two types of receptors –ionotropic GABAA and metabotropic GABAB. The GABAA receptor directly gates a Clionophore that causes ...