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Biochemical And Molecular Insights Into β-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) From Plasmodium Falciparum
(2008-10-14)
Malaria, caused by Plasmodium, is one of the most devastating infectious diseases of the world in terms of mortality as well as morbidity (WHO, 2002). The development of resistance in the Plasmodium falciparum against the ...
Components Of Fatty Acid Synthesis In Plasmodium Falciparum
(2008-10-17)
The disease malaria afflicts more than a billion people and kills almost one
to three million of them every year. Of the four species of Plasmodium affecting man viz., P. falciparum, P. vivax, P. ovale and P. malariae, ...
Folding Studies On Peanut Agglutinin : A Lectin With An Unusual Quaternary Structure
(2009-03-04)
The thesis entitled “Folding studies on Peanut Agglutinin: A lectin with an unusual quaternary structure” deals with the several aspects of the folding of the tetrameric legume lectin Peanut Agglutinin ...
Mechanism Of Anticancer And Antimalarial Action Of A Modulator Of Heat Shock Proteins
(2007-11-16)
This thesis entitled “Mechanism of Anticancer and Antimalarial Action of
a Modulator of Heat Shock Proteins” describes the successful elucidation of the
mechanism of anticancer and antimalarial action of 15-Deoxyspergualin ...
Structural Studies On Enzymes From Salmonella Typhimurium Involved In Propionate Metabolism: Biodegradative Threonine Deaminase, Propionate Kinase And 2-Methylisocitrate Lyase
(2007-11-23)
I formally joined Prof. M. R. N. Murthy’s laboratory at the Molecular Biophysics
Unit, Indian institute of Science, on 1st August 2001. During that time, the interest in the laboratory was mainly focused on structural ...
Interaction Of Chaperone SecB With Protein Substrates: A Biophysical Study
(Indian Institute of Science, 2006-10-17)
In the cell, as in in vitro, the final conformation of a protein is determined by it's amino acid sequence (1). Some isolated proteins can be denatured and refolded in vitro in absence of extrinsic factors. However, in ...
Structural Investigations Of Sugar-Binding And Multivalency In Peanut Lectin
(2009-03-04)
Starting with the structure analysis of ConA in the 70s, the crystal structures of hundreds of different lectins and their carbohydrate complexes have been determined. Lectins, multivalent carbohydrate-binding proteins ...
Structure Function Studies Of Biologically Important Simple Repetitive DNA Sequences
(Indian Institute of Science, 2007-03-09)
The recent explosion of DNA sequence information has provided compelling evidence for the following facts. (1) Simple repetitive sequences-microsatellites and minisatellites occur commonly in the human genome and (2) these ...
Intracellular Calcium Dynamics In Dendrites Of Hippocampal Neurons Rendered Epileptic And In Processes Of Astrocytes Following Glutamate Pretreatment
(2009-04-03)
The fundamental attribute of neurons is their cellular electrical excitability, which is based on the expression of a plethora of ligand- and voltage-gated membrane channels that give rise to prominent membrane currents ...
Garlic (Allium Sativum) Agglutinin I: Specificity, Binding And Folding Mechanism
(Indian Institute of Science, 2006-11-08)
Lectins are a class of proteins that bind to carbohydrates with a high degree of specificity. They are involved in various cellular processes such as, host - pathogen interactions, targeting of proteins within cells, cell ...