Adaptation to a rapidly fluctuating environment is the key to the survival of an organism. Bacteria sense and respond to stress by an overall reprogramming of the cellular processes to shut down the energy-consuming processes ...

Protein homeostasis in all organisms is a complex process involving regulatory mechanisms that govern protein synthesis, post-translational events and degradation. The protein degradation mechanism serves multiple functions ...

TREK1 is a two-pore domain leak potassium channel which contributes to resting membrane potential. TREK1-/- mice exhibit increased neuronal mortality after global ischemia. Neuroprotective agents like volatile anesthetics ...

Single-stranded RNA virus infection cycle progresses by resource (viral RNA) allocation to segregated macromolecular complexes: host ribosomes (translation), viral RNA polymerase (replication) and viral structural proteins ...

Tuberculosis is the second largest killer disease on global scale after HIVAIDS. The rapid evolution of Mycobacterium tuberculosis into drug resistant strains and the toxicity of these drugs are the major constraints in ...

Tuberculosis (TB) is a deadly disease responsible for the death of approximately 1.5 million people each year, with the highest being from developing nations. Tuberculosis affects mostly the lungs, and other parts of the ...

This thesis is concerned with structural and related studies on two non-toxic homologues of type II RIPs. Type II RIPs, which are more toxic than type I, contain an additional lectin chain (B-chain) covalently linked to ...

Genomic integrity is a fundamental requisite for survival and proliferation of all organisms. The genetic material is continuously threatened by a multitude of extrinsic and intrinsic factors. Consequently, the presence ...

Maintenance of the genomic integrity of the cell is crucial for the survival and successful propagation of an organism. However, this integrity is under continuous threat from DNA-damaging agents. In addition, errors in ...

Structural biology deals with determining the structure of biological macromolecules especially proteins, DNA, RNA. The conformational changes in the structure of a macromolecule helps to decipher its function. This ...