Search
Now showing items 41-50 of 52
Solution Structure Studies on the Effects of Aromatic Interactions and Cross-Strand Disulfide Bonds on Protein Folding
(2018-07-05)
The work presented in this thesis focusses primarily on the determination of protein structure at atomic resolution, with NMR spectroscopy as the principle investigative tool. The thesis is divided into four parts. Part I ...
Secondary Structures in Proteins : Identification and Analyses
(2018-07-12)
Proteins are large biomolecules consisting of one or more long chains of amino acid residues. They perform a vast array of functions within living organisms. In this thesis, we present analyses of different secondary ...
Design and Stabilization of Stem Derived Immunogens from HA of Influenza A Viruses
(2018-07-19)
Influenza virus belongs to the Orthomyxovirus family of viruses that causes respiratory infection in humans, leading to morbidity and mortality. The mature influenza A virion has an envelope that contains two major surface ...
Structural and Functional Studies on Pyridoxal Kinase and Pyridoxal 5′-phosphate Dependent Enzymes
(2018-07-04)
Most of the chemical reactions of living cells are catalyzed by protein enzymes. These enzymes are very efficient and display a high degree of specificity with respect to the reaction catalyzed. Cellular activities depend ...
Physiological Interactions between Neuronal Active Conductances And Inositol Trisphosphate Receptors in Neurons and Astrocytes
(2018-07-23)
Intricate interactions among constituent components are defining hallmarks of biological systems and sculpt physiology across different scales spanning gene networks to behavioural repertoires. Whereas interactions among ...
In Silico Perspectives on RNA Structures Modulating Viral Gene Expression and Mechanics of tRNA Transport
(2018-07-19)
The repertoire of cellular functions mediated by Ribonucleic acid (RNA) molecules have expanded considerably during the last two decades. The role played by RNA in controlling and regulating gene expression in ...
Modulation of Protein Stability and Function by Cysteine Mutations and Signal Peptides
(2018-06-23)
Chapter 1gives a general introduction to the CXXC motif found in natural proteins. It then reviews the studies where disulphides were engineered in various proteins. The various strategies developed to engineer metal binding ...
Development of a Selective Cell-Permeable Protein Phosphatase 1 Inhibitor
(2018-07-10)
Selective ‘super-specific’ inhibitors of Protein Phosphatase 1 (PP1) are not available. Several natural product toxins possessing marginal selectivity between PP1 and the closely related Protein Serine/Threonine Phosphatase ...
Computational Analyses of Protein Structure and Immunogen Design
(2018-08-20)
The sequence of a polypeptide chain determines its structure which in turns determines its function. A protein is stabilized by multiple forces; hydrophobic interaction, electrostatic interactions and hydrogen bond formation ...
The Role of DNA Structural Features of Eukaryotic Promoter Sequences in Transcription Regulation
(2018-09-04)
Understanding the molecular structure of DNA was considered as greatest achievement in modern biology. It helped in understanding fundamental cellular processes such as replication of DNA, nature of the ...