etd AT Indian Institute of Science: Recent submissions
Now showing items 21-40 of 8174
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Unraveling the layers of DNA with the DNA-PAINT brush
DNA is both the repository of genetic information and a versatile nanoscale material whose stability and function are governed by base pairing and base-stacking interactions. Despite their fundamental role in DNA structure, ... -
Design, development, and clinical validation of KaraMetrics: A sensor-based hand function assessment tool for stroke rehabilitation
Stroke is a leading cause of adult disability worldwide, with persistent hand dysfunction severely limiting independence and quality of life for survivors. Existing clinical assessments of hand function such as the Fugl-Meyer ... -
Mechanobiology of Liver Fibrosis: Role of Hepatocytes in Fibrosis Progression
Liver fibrosis is characterized by liver scarring which disrupts the liver architecture and impairs hepatic function. Current diagnostic tools reveal that the stiffness of the liver tissue increases as one advances through ... -
On some structural problems in the theory of infinite-dimensional Lie (super)algebras
In this thesis, we examine two facets of infinite-dimensional Lie algebras. The first part focuses on the classification of $\pi$-systems in rank 2 Kac-Moody Lie algebras. In one of his seminal works, Dynkin classified the ... -
Studies on the roles of Lon protease and its substrates during antibiotic resistance in Escherichia coli: modulatory effects of nitroaromatics and nitrofurantoin
Bacteria adapt to environmental stresses, including antibiotic stress, by regulating various genes and metabolic pathways. In prokaryotes, the energy-dependent protein degradation is controlled primarily by two ... -
Core-Shell Precipitates in Ternary Alloys: A Phase-Field Study
Since the discovery of age hardening, a large number of alloys have been produced that exploit the presence of one or more precipitate phases in the microstructure for strength enhancement. In recent decades, alloys with ... -
Chemical Modulation of Ferroptosis in Mammalian Cells by Synthetic Organoselenium and Gold-based Small Molecules
Oxidative stress induced by reactive oxygen species (ROS) plays a crucial role in triggering various forms of cell death, including apoptosis, autophagy, and necrosis. In recent years, a distinct and regulated form of cell ... -
Patterns and drivers of elevational migration in Himalayan birds
Migration is a behavioural strategy that species use to deal with seasonal variation in climate and resources. A common form of migration is elevational migration, which is a short-distance movement undertaken by mountain ... -
Decoding determinants of selectivity in biomolecules
Molecular events demonstrate remarkable specificity amid complexity in its cellular environment. This phenomenon, termed biomolecular recognition, is fundamental to the organization and regulation of biological systems. ... -
Global response sensitivity and reliability analyses of structural dynamical systems with parameter and excitation uncertainties
This thesis develops computational methods for global response sensitivity analysis (GRSA) and time-variant reliability analysis in structural dynamical systems with parameter and excitation uncertainties. The primary ... -
Elastic Wave Dispersion Analysis and Mode Shape Investigation of Higher order Beam Theory for Thick Beams
The dynamic behavior of structural components, particularly thick beams, is critical in many engineering applications, including aerospace engineering, civil infrastructure, and mechanical systems. The rigid cross-section ... -
Autonomous Motion, Control Strategies & Sensing Applications Using Magnetic Micro-Robots
In recent years, there has been growing interest in manoeuvring nanoscale objects in fluidic environments, as it holds significant potential in targeted therapies, diagnostics, and probing local rheological properties. ... -
PSD95 as a biophysical modulator of synaptic communication
PSD95 is a core scaffold protein of the postsynaptic density (PSD) at excitatory synapses and a member of the MAGUK family, where it plays a central role in organizing glutamate receptors, ion channels, and signalling ... -
Ultrafast Photophysics of Aminoboranes by Transient Absorption and Ultrafast Raman Loss Spectroscopy
B–N based aminoboranes systems have recently emerged as promising materials for organic optoelectronic and biomedical applications. They exhibit a wide range of functionalities such as delayed fluorescence, room-temperature ... -
Automating SAPPhIRE Modeling for Product Systems and Extending SAPPhIRE Model to Service Representation
Creativity in product design sparks innovation, leading to unique solutions that meet evolving consumer needs. This innovation drives economic growth by creating new markets and job opportunities. Moreover, creative product ... -
Hyperspectral Image Fusion with Implicit Regularization
Hyperspectral (HS) satellite images contain rich spectral information but generally suffer from low spatial resolution. In contrast, multispectral (MS) images offer higher spatial resolution but only a limited number of ... -
Investigations on nuclear pulse-height analysis with applications to studies of radioactive minerals
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Cosmic noise studies in relation to ionospheric absorption and solar activity
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Scaling and universality in driven systems : the sandpile model and the GOY shell model of turbulence
In spite of their simplicity, sandpile models have proved to be very useful for studying (a) SOC in model systems and (b) nonequilibrium steady states in driven systems. As we have mentioned in the brief overview given ...