etd AT Indian Institute of Science: Recent submissions
Now showing items 41-60 of 6562
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Integrative multiscale modeling and simulations of biomolecules with experimentally testable predictions
This thesis delves into four separate research works related to Integrative multiscale modeling and simulations of biomolecules. The first work deals with the puzzling case of the Pleckstrin Homology Domain (PHD), which ... -
Unraveling the role of cellular phosphatases in lysosome function and storage diseases
Investigating the role of DUSP14 and Rab7A in endo-lysosomal trafficking in mammalian cells Eukaryotic cells maintain homeostasis and interact with their environment through intricate metabolic processes, including the ... -
Single and Multi-Agent Finite Horizon Reinforcement Learning Algorithms for Smart Grids
In this thesis, we study sequential decision-making under uncertainty in the context of smart grids using reinforcement learning. The underlying mathematical model for reinforcement learning algorithms are Markov Decision ... -
Crafting Complexity: Characterization and Tuning of Non-Hermitian Topological Phases
Quantum mechanics relies on self-adjoint or Hermitian operators, ensuring real eigenenergies and preserving probability via a unitary time evolution [1]. However, this applies strictly to closed systems. In open systems, ... -
Role of RTEL1 helicase in the regulation of homologous recombination during DNA replication
Homologous recombination (HR) plays an essential role in the repair of DNA double-strand breaks (DSBs), replication stress responses, and genome maintenance. Although the mechanism of HR has been extensively studied in the ... -
Analysis, Modelling, and Optimization of Gate-To-Gate Aircraft Operation for Enhanced Air Traffic Management
The global air passenger demand will surpass the 10 billion mark by the end of 2040. India itself is poised to become the third largest aviation market and traffic generator by 2033, with a forecast of over 950 million ... -
Sparse Input View Synthesis: 3D Representations and Reliable Priors
Novel view synthesis refers to the problem of synthesizing novel viewpoints of a scene given the images from a few viewpoints. This is a fundamental problem in computer vision and graphics, and enables a vast variety of ... -
Universal and Scalable Multi-Source Energy Harvesting Power Supply with Dynamic Load Adaptation
Autonomous powering of electronic systems in applications spanning biomedical, automation, transportation and space industries relies on harvesting energy from the abundant ambient sources such as vibration, thermal, solar, ... -
Unravelling Crosstalk in Two-component Signalling Systems and Its Role in Mycobacterium Species
A typical two-component signaling system (TCSs) is composed of two transcriptionally coupled proteins (cognate pair) where one is a signal-sensing histidine kinase (HK) and the other, an output-generating response regulator ... -
Emergence and Propagation of Aerodynamic Instabilities in Centrifugal Compressors with Vaned Diffusers: Effect of Solidity and Stagger
Centrifugal compressors are widely employed in turbochargers and small gas turbines due to their ability to achieve high compression per stage. These compressors consist of a rotating impeller and a static diffuser, which ... -
Dual-Mode Operation of Grid-tied Inverters: Modeling, Islanding Detection and Transfer of Control
Increased penetration of renewable energy sources like solar and wind is fundamentally altering the power flow dynamics in modern distribution networks. These distributed generations (DG) boost system reliability by enabling ... -
Elucidation of the structure-function relationship of the Saccharomyces cerevisiae HORMA domain-containing proteins Hop1 and Rev7
DNA-based transactions like replication, repair, recombination and transcription are central to survival, inheritance and evolution. Not surprisingly, these mechanisms are tightly regulated by a myriad of protein-protein, ... -
Invariants Associated with Complete Nevanlinna-Pick Spaces
The broad aim of this thesis is to study certain tuples of bounded operators that satisfy an operator inequality arising from a complete Nevanlinna-Pick kernel. Specifically, we focus on two invariants of these operator ... -
Maps Between Non-compact Surfaces
This thesis focuses on studying proper maps between two non-compact surfaces with a particular emphasis on the topological rigidity and the Hopfian property. Topological rigidity is the property that every homotopy equivalence ... -
Sandwiched Hybrid Waveguide Platform for Integrated Photonics Applications
Guided wave optical technology, made possible by the invention of lasers and low-loss optical fibers, has revolutionized communication over the past century. With their high bandwidth capabilities, optical fibres have ... -
On structure preserving numerical schemes for hyperbolic partial differential equations and multiscale kinetic equations
Natural phenomena are frequently represented through the formulation of differential equations, coupled with specific initial and boundary conditions. Many such models possess inherent structures that are crucial in ... -
Studies on the mechanisms of action and the physiological roles of MutT1 in mycobacteria
Mycobacterium tuberculosis (Mtb), a pathogenic bacterium, thrives and proliferates inside host macrophages, encountering a high level of reactive oxygen species and reactive nitrogen intermediates which is generated by the ... -
Investigation of Microbes and Blood Plasma Towards Implications in Biomedicine: A Raman Spectroscopic Study
Raman spectroscopy, combined with artificial intelligence, is becoming increasingly popular in biology because of its sensitivity to molecular changes. This thesis discuss the applications of Raman spectroscopy in analysing ... -
Investigations on Single DC Source Hybrid Multilevel Topologies with Extended Linear Modulation Range for Variable Speed Drives
Multilevel inverters (MLIs) are preferred for high and medium power applications due to their numerous advantages over traditional two-level inverters. MLIs generate output phase voltages with multiple levels, mitigating ... -
Developing Decision Support for Electric Vehicle (EV) Adoption & Charging Infrastructure Planning
Majorly reliant on petroleum products, the transportation sector accounts for 25% of the global energy demand and 23% of carbon dioxide emissions. Among all the modes of transportation, road vehicles are the primary sources ...