etd AT Indian Institute of Science: Recent submissions
Now showing items 41-60 of 6746
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Insights into ISWI group Chromatin Remodeler BAZ1A (bromodomain adjacent to zinc finger domain 1A): A Key Player of E2F transcription program in glioma
ISWI (Imitation Switch) family of chromatin remodeling complexes mobilize nucleosomes to control DNA accessibility, which manages various DNA template-associated processes like replication, transcription, and repair. ... -
Investigating the neural basis of spatial attentional components with probabilistic and reward cueing
We are constantly inundated with an abundance of sensory information. “Attention” enables the selection of relevant information and filtering out irrelevant information, to guide adaptive behavior. While attention can be ... -
Molecular Interactions Between SARS-CoV-2 Viral and Human Cellular Factors: Implications for Viral Infection, Replication, and Disease
The COVID-19 pandemic was this century's most significant global public health crisis. The causative agent was SARS-CoV-2, an enveloped, single-stranded positive-sense virus. As an obligate intracellular pathogen, SARS-CoV-2 ... -
Advanced Thermoplastic Laminates with Tailored Interface for Aerostructures
Carbon fiber reinforced polymer (CFRP) laminates are currently used in commercial aircrafts replacing their metallic counterparts. Epoxy is used as matrix in CFRPs in the primary structures of aircrafts such as fuselage, ... -
Development of Microsystem Platforms Towards Cancer Diagnostics and Therapeutics
This thesis explores the development and application of microsystems to advance our understanding of disease biology. The overarching goal is to enhance diagnostic and therapeutic strategies through precise and physiologically ... -
Improving Efficiency of Perovskite and Silicon Solar Cells by Reducing Surface Recombination, Bulk Recombination, and Thermalization Losses
Solar photovoltaic (PV) technology stands at the forefront of renewable energy solutions, driven by the urgent need to mitigate climate change and secure sustainable energy sources. As the demand for cleaner energy ... -
Confronting realistic MHD simulations of solar eruptions with observed space based data
Solar flares and Coronal Mass Ejections (CMEs) are among the most violent and energetic phenomena observed in the solar atmosphere, resulting from the sudden release of immense amounts of energy. A typical solar flare is ... -
Switchable Magnetic Materials Derived from Octacyanometallates
Molecule-based magnetic materials encompass an advancing class of bistable materials that have garnered significant attention due to their intriguing physical properties and potential practical applications. These materials ... -
Cyclic nucleotide-binding proteins in mycobacteria
Mycobacterium tuberculosis, one of the leading causes of death worldwide even today, employs the second messenger cAMP extensively for its pathogenicity and persistence. Intracellular and extracellular levels of cAMP in ... -
Design and diagnostics of gas turbine combustors: from high shear injector to full-scale sector of annular combustor
The aviation industry, like many others, has to meet stringent pollution and emission norms due to climate change and global warming. Aircraft engines burning fossil fuels emit pollutants such as NOx, CO, and soot, impacting ... -
Lesion Synthesis using Physics-Based Noise Models for Low-Data Medical Imaging Regime applications
Lesion segmentation and their progression prediction in medical imaging relies critically on the availability of manually annotated, heterogeneous large pathological datasets. Acquiring such diverse large datasets is also ... -
Elucidating the diverse functions of RGG-motif containing proteins
One year embargo upto 20/2/2026 RGG-motif containing proteins represent one of the major subsets of RNA-binding proteins characterized by the presence of RGG/RG repeats. These proteins have been associated with a wide ... -
Self-propulsion in Pitching Airfoils
Self-propelled oscillating foils are simple yet useful models that can be used to explore the physics of oscillatory bio-locomotion. In this investigation, we explore the self-propulsion characteristics of a rigid NACA0015 ... -
N-Heterocyclic Carbene-Catalyzed Enantioselective Synthesis of C-O Axially Chiral Diaryl Ethers, Tricyclic Lactones and Lactams
N-heterocyclic carbene (NHC)-catalyzed transformations with distinctive activation modes allow the facile synthesis of atropoisomers. In this context, we have demonstrated the NHC-catalyzed synthesis of axially chiral diaryl ... -
Engineering Quality Factor in Micro/Nano Resonating Devices
Micro/Nano resonating devices offer enormous potential and have distinctive features for building sensors and actuators. One of the key parameters that control the response of these devices is Quality Factor (Q). Q is ... -
Learning from Limited and Imperfect Data
Deep Neural Networks have demonstrated orders of magnitude improvement in capabilities over the years after AlexNet won the ImageNet challenge in 2012. One of the major reasons for this success is the availability of ... -
Interaction of the TCP4 protein with other transcription factors and its effect on Arabidopsis shoot apex
The TEOSINTE BRANCHED1, CYCLOIDEA, PROLIFERATING CELL FACTORs (TCP) class of proteins are plant-specific transcription factors with a non-canonical basic helix-loop-helix (bHLH) domain involved in both DNA-binding and ... -
An investigation of the sensitivity of climate feedbacks to the latitudinal distribution of radiative forcing using the radiative kernel approach
It is well known that climate sensitivity, defined as the global mean surface temperature change per unit radiative forcing, depends on the forcing agents (such as CO2, CH4, O3, aerosols, solar radiation, land cover change, ... -
Quantum and classical hardware development for superconducting qubits
The journey toward realizing practical quantum computing involves overcoming critical challenges in qubit architecture, robust gate performance, and scalable control systems. This thesis addresses these challenges through ... -
Role of HCN Currents (Ih) in Epileptiform Activity in Subicular Neurons
Subicular burst firing neurons are established as primary instigators of seizure onset and propagation in Temporal Lobe Epilepsy (TLE), a form of focal epilepsy that accounts for approximately 60% of all epilepsy cases in ...