Department of Developmental Biology & Genetics (DBG, earlier called MRDG): Recent submissions
Now showing items 41-60 of 149
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Influence of Tgf-B on Mechanobiology of Human Breast Cancer Cells
Breast cancers are characterized by extensive modifications to mechanical properties of the tissue via increased ECM production and vascularization. TGF-B is a multi-functional cytokine that is implicated in cancer invasion ... -
Dissecting the role of Ataxin 2 Binding Protein 1 in sarcomeric protein stoichiometry and generation of muscle diversity in Drosophila melanogaster
Drosophila muscles are an excellent model to study muscle development, diversity and function. Drosophila muscles consist of two major types –1. Indirect Flight Muscles (IFM), that are fibrillar; as opposed to other tubular ... -
Studies on differentiation of mouse GS-2 ES-cells to pancreatic β-islet-like cells and their functional maturation status
Embryonic stem cells (ES-cells) are an excellent source for generating insulin-producing β-islet cells for potential use in the management of diabetes mellitus. Although many protocols have been developed to promote the ... -
Effects of Steroid Hormones on Insulin Sensitivity and Lipogenesis: An Insight into the Involvement of the Wnt Signaling Pathway
The shift in maternal energy metabolism characteristic of pregnancy is thought to be driven by various hormonal changes, especially of ovarian and placental steroids. In this context, the effect of estradiol (E2), progesterone ... -
Biochemical and functional characterisation of cyclic AMP-binding, universal stress proteins from mycobacteria
The genus Mycobacterium harbours several pathogenic species, including M. tuberculosis, the causative agent of tuberculosis, which alone is responsible for nearly 1.3 million deaths globally every year. Understanding the ... -
Ageing associated altered host response to bacterial infection
Chapters in which I have elucidated and elaborately described how senescence alters the cellular response to infection, here I demonstrate how senescence in multiple tissues simultaneously contribute to pathogen spread and ... -
Pathogen-derived volatiles modulate flight or fight response in Caenorhabditis elegans
In nature, the interaction between two organisms largely relies on their ability to sense and respond to each other, which involves many specific chemicals and signaling pathways. Animals have evolved mechanisms to detect ... -
Deciphering the evolutionary significance of maintaining cryptic genetic systems by bacteria
Cryptic genes are phenotypically silent DNA sequences with the potential to code for a function, but remain inactive during the normal life span of the organism. However they can be activated by a single mutational event ... -
Post-transcriptional regulation of the tumor suppressor gene TSC1 and its relevance in Oral Squamous Cell Carcinoma
Oral cancer or oral squamous cell carcinoma (OSCC) is a subset of head and neck cancer (excluding non-melanoma skin cancer), with an estimated 354,864 new cases and 177,384 deaths reported annually. India accounts for 34% ... -
Glycobiological Regulation of Breast Cancer Invasion
Invasiveness of cancer is the predominant reason behind mortality associated with the disease. Although long under active investigation, fundamental aspects of the early steps of cancer invasion and metastasis are still ... -
Investigating the mechanisms of cancer drug resistance
Clinical chemo-resistance has posed a challenge to scientists and clinicians since the development of chemotherapeutics as anticancer strategy. Mechanisms of drug resistance continue to be a subject investigation amongst ... -
Spatio-temporal Regulation of GPCR mediated MAPK Transactivation in Living Cells
Signal transduction is a mode of cellular communication essential for an organism’s sustenance and survival. Cell communication in higher organisms is largely executed by two classes of cell surface receptors i.e. G-protein ... -
Deciphering the genetic regulators of cuticle barrier function and longevity in Caenorhabditis elegans
Ever since Sydney Brenner introduced Caenorhabditis elegans in the early 60s as a model system, this worm has contributed to many ground-breaking discoveries in science. It has served as an excellent model to study animal ... -
Functional Characterization of CG9650 in development of the Indirect Flight Muscles of Drosophila melanogaster
Muscle development is a complex and multifactorial process involving assembly of thousands of proteins in a precise and synchronized manner over the course of development of an organism. Multiple genes and signalling ... -
Identification and Characterization of Molecular and Genetic Regulators of Cellular Senescence - Role of Free Radical Homeostasis
Aging is defined in an evolutionary biological context as a steady state decline in the specific fitness components of an organism due to internal physiological deterioration. The most profound and important contribution ... -
Mechanism of β-catenin regulation by IGFBP2: Role in Glioblastoma progression
Insulin-like growth factor binding proteins (IGFBPs) were initially identified as high affinity binders of Insulin-like growth factors (IGFs). There are six IGFBPs which regulate the bioavailability and functions of IGFs ... -
Rv0805, a novel regulator of central carbon metabolism and cell envelope properties in mycobacteria
Metabolic flexibility is one of the key factors that underpin mycobacterial physiology and pathogenesis. During infection, mycobacteria shift towards utilising host-derived fatty acids, lipids, cholesterol and cholesterol-esters. ... -
Regulation of S100A2 by TGF-B : Role in Epithelial -mesenchymal Transition and Tumor Growth
Transforming growth factor-β (TGF-β) is a multifunctional cytokine that regulates a plethora of functions including cell growth, development, and differentiation. TGF-β plays a major role in the inhibition of normal cell ... -
Embryonic Expression of Cytokines: Functional Role of Il-1β During Blastocyst Hatching
The detailed investigation on the embryo-endometrial cytokine expression, in both mouse and hamster, was carried out during the peri-hatching development and it is described in chapter 2. We hypothesize that, for a ... -
Immune-metabolic response of Caenorhabditis elegans to Enterococcus faecalis
Immune response to pathogens is energetically expensive to the host. In this study, we show that Caenorhabditis elegans exposed for 8 hours to pathogenic Gram-positive bacteria, Enterococcus faecalis and Staphylococcus ...