Department of Developmental Biology & Genetics (DBG, earlier called MRDG): Recent submissions
Now showing items 121-140 of 155
-
Stress Signaling In Development And Carcinogenesis : Role Of AMP-Activated Protein Kinase
(2013-08-05)Rapidly growing tumor cells outgrow their blood supply resulting in a microenvironment with reduced oxygen and nutrients. Using an in vitro transformation model we found that cancer cells expressing the SV40 ST antigen ... -
Unravelling The Mechanisms Of Myofibrillogenesis And Human Myopathies Using Drosophila Mutants
(2013-07-18)Myofibrillogenesis is a complex process, which involves assembly of hundreds of structural proteins in a highly ordered manner to form the contractile structural unit of muscle, the sarcomere. Several myopathic conditions ... -
Studies On Embryonic Stem Cells From Enhanced Green Fluorescent Protein Transgenic Mice : Induction Of Cardiomyocyte Differentiation
(2013-07-17)Genesis of life begins with the fusion of female and male haploid gametes through a process of fertilization leading to the formation of a diploid cell, the zygote. This undergoes successive cleavage divisions forming 2-, ... -
Functional Analysis Of Primary Microcephaly Gene Product ASPM
(2013-06-20)Autosomal recessive primary microcephaly (MCPH) is defined by congenital microcephaly and associated mental retardation with head circumference of the affected individual at least 3 standard deviations below age- and ... -
Cyclic AMP In Mycobacteria Adenylyl Cyclases And Cyclic AMP Receptor Proteins
(2013-01-28)The discovery of cyclic AMP (cAMP), nearly 50 years ago by Sutherland radically altered the appreciation of metabolic regulation. Since then the presence of cAMP and its tremendous physiological impact has been demonstrated ... -
A Novel Family Of Soluble Diacylglycerol Acyltransferases
(2011-10-04) -
Studies On Intracrine Regulators Of Ovarian Function : Examination Of Progesterone Action On Structure And Function Of Corpus Luteum In The Monkey
(2011-08-09)The control of reproductive cycles in higher primates is largely dependent on negative and positive feedback mechanisms by both steroidal and non-steroidal substances of the ovaries which regulate the function of ... -
Characterization Of Down Regulated Genes In Astrocytoma
(2011-07-27)Gliomas are the most common primary brain tumors and include astrocytomas, oligodendrogliomas and oligoastrocytomas. Astrocytomas have a high frequency of occurrence as compared to the other gliomas and several studies ... -
A Study Of The Roles Played By The Trishanku Gene In The Morphogenesis Of Dictyostelium Discoideum
(2011-02-22)A hallmark feature of Dictyostelium development is the establishment and maintenance of precise cell-type proportions. In the case of D. discoideum, roughly 20% of the cells that aggregate form the stalk while the remaining ... -
Molecular Characterization Of The SLC22A18AS Gene From The Imprinted Human Chromosome Segment 11p15.5
(2011-02-21)The imprinting status of the SLC22A18AS gene, located in the human chromosome segment 11p15.5, was studied using PCR-SSCP analysis and fetal tissues from a battery of 17 abortuses. This gene showed monoallelic expression ... -
Epigenetic Regulators Of Development In The Social Amoeba Dictyostellium Discoideum : The Roles Played By Histone Deacetylases And Heat Shock Protein 90
(2011-01-20)The major evolutionary transition from single-celled to multicellular life is believed to have occurred independently of the main metazoan lineages in the cellular slime moulds, of which Dictyostelium discoideum is the ... -
Characterization Of Human Mammary Stem Cells Grown As Mammospheres
(2011-01-11)Adult stem cells are a small population present within several tissues of an individual, possessing two unique properties: one, the ability to differentiate to give rise to all the cell types of the tissue, and second, the ... -
Biochemical And Functional Characterization Of Evolutionarily Conserved Metallophosphoesterases The 239FB/AB Family
(2010-12-30)With the advent of large scale genome sequencing efforts along with more sophisticated methods of genetic mapping, a number of loci have been identified that are associated with human diseases. Intriguingly, many genes ...