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Investigations on the Possible Role of Aromatic β-Glucoside Metabolism in Self-Defense in Enterobacteriaceae
(2018-04-02)
Bacteria are ubiquitous in all ecosystems and are often challenged by multiple stresses such as extreme temperatures, high salt concentrations, nutrient limitation, pH variations, radiation, predation and the presence of ...
Molecular Phenotyping of Mutations in Guanylyi Cyclase C Associated with Congenital Diarrhea
(2018-02-28)
Guanylyl cyclase C (GC-C) is a member of particulate guanylyl cyclases, discovered primarily as the target of a family of heat stable enterotoxins (ST), produced by enterotoxigenic Escherichia coli (ETEC). ST is acknowledged ...
Spermatogenomics : Correlating Testicular Gene Expression to Human Male Infertility
(2018-06-13)
Spermatogenesis is a complex and coordinated process of formation of sperms from the precursor spermatogonia, occurring inside the unique environment existing in the seminiferous epithelium. This process of development, ...
Moonlighting Functions of the Rv0805 Phosphodiesterase from Mycobacterium Tuberculosis
(2018-04-18)
All organisms must sense and respond to their environment in order to survive. The processes that allow a living cell to sense changes in its environment, and respond appropriately are collectively referred to as ‘signal ...
Biochemical and Functional Studies on the Evolutionarily Conserved MPPED1/MPPED2 Protein Family
(2018-05-16)
A large number of evolutionarily conserved genes have been identified by comparative genomics approaches. However, a considerable fraction of these genes lack functional characterization despite the availability of several ...
Targeting Gonadotropins to the Dendritic Cells : A Novel Strategy for Animal Immunocontraceptive Vaccine
(2018-05-09)
Contraception through a vaccine has been a very attractive proposition and several attempts were made in the past. To achieve contraception through immunological means, several points need to be considered. First, the ...
Transcriptional and Posttranscriptional Regulation of the Tumor Suppressor CDC73 in Oral Squamous Cell Carcinoma : Implications for Cancer Therapeutics
(2018-04-16)
CDC73, also known as HRPT2, is a tumour suppressor gene whose expression is lost or downregulated in parathyroid, renal, breast, uterine and gastric cancers. However, the reports regarding the role of CDC73 in oral squamous ...
Unfolding the Mechanism of Notch1 Receptor Activation : Implications in Cancer Stem Cell Targeting
(2018-05-01)
Notch receptors and ligands are single-pass transmembrane proteins which play important roles in cell-cell communication. Notch in ‘harmony’ with other signaling pathways regulate the entire diversity of metazoan life ...
Regulation of Chitin Oligosaccharides Utilization in Escherichia Coli
(2018-04-11)
The genome of Escherichia coli harbors several catabolic operons involved in the utilization of a wide variety of natural compounds as carbon sources. The chitobiose (chu) operons of E.coli Is involved in the utilization ...