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    Browsing Department of Developmental Biology & Genetics (DBG, earlier called MRDG) by Subject 
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    • Department of Developmental Biology & Genetics (DBG, earlier called MRDG)
    • Browsing Department of Developmental Biology & Genetics (DBG, earlier called MRDG) by Subject
    •   etd@IISc
    • Division of Biological Sciences
    • Department of Developmental Biology & Genetics (DBG, earlier called MRDG)
    • Browsing Department of Developmental Biology & Genetics (DBG, earlier called MRDG) by Subject
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    Browsing Department of Developmental Biology & Genetics (DBG, earlier called MRDG) by Subject "Research Subject Categories::NATURAL SCIENCES::Biology::Cell and molecular biology"

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    Now showing items 1-20 of 32

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      • Activin and TGF-β signaling: Differential role of a Serine/Threonine phosphate in the regulation of SMAD2 activity 

        Gautam, Srishti
        Activins are the most prominent members of the Activin/Inhibin branch of the TGF-β superfamily. Similar to TGF-β, they play an essential role in regulating multiple physiological processes such as development, reproductive ...
      • Biochemical and functional characterisation of cyclic AMP-binding, universal stress proteins from mycobacteria 

        Banerjee, Arka
        The genus Mycobacterium harbours several pathogenic species, including M. tuberculosis, the causative agent of tuberculosis, which alone is responsible for nearly 1.3 million deaths globally every year. Understanding the ...
      • Biochemical and Functional Characterization of the Mycobacterial PdtaS-PdtaR Two Component System 

        Hariharan, Vignesh Narayan
        Two-Component Systems (TCSs) are primarily prokaryotic modes of cell signaling involving a receptor sensor kinase (SK) that senses stimuli and a response regulator (RR) that effects a response, usually at the level of ...
      • Biochemical and structural studies to provide insights into initiator tRNA delivery by eIF2A in noncanonical translation initiation 

        Parida, Bijayalaxmi
        Eukaryotic initiation factor 2A (eIF2A), a non-canonical translation initiation factor, delivers initiator tRNA (tRNAi) onto the 40S ribosomal subunit in a codon-dependent and GTP-independent manner, unlike the canonical ...
      • Cyclic nucleotide-binding proteins in mycobacteria 

        Chakraborty, Moubani
        Mycobacterium tuberculosis, one of the leading causes of death worldwide even today, employs the second messenger cAMP extensively for its pathogenicity and persistence. Intracellular and extracellular levels of cAMP in ...
      • Deciphering the evolutionary significance of maintaining cryptic genetic systems by bacteria 

        Vashishtha, Kartika
        Cryptic genes are phenotypically silent DNA sequences with the potential to code for a function, but remain inactive during the normal life span of the organism. However they can be activated by a single mutational event ...
      • Deciphering the function of sesaminol as an anti-obesity and anti-MAFLD molecule 

        Rajprabu, R
        Obesity and its associated metabolic diseases, including type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) or metabolic dysfunction-associated liver disease (MAFLD), pose significant global health challenges. ...
      • Development of 3D model and understanding translational regulation of breast cancer 

        Manjunath, Sathish
        Breast cancer is the most common cancer among women in India and worldwide. It is a highly heterogeneous disease caused by several genetic and epigenetic alterations in mammary epithelial cells. Both inter- and intra-patient ...
      • Differential DNA methylation patterns in primary and recurrent glioblastomas : Protumorigenic roles of Tumor Endothelial Marker 8 (TEM8) and ASAP1 genes 

        Kundu, Paramita
        Glioblastomas (GBMs) are clinically aggressive malignant brain tumors in adults with a median survival of 14 months on diagnosis. Therapeutic interventions such as debulking surgeries, chemotherapy, and ionizing radiation, ...
      • Dissecting the role of Ataxin 2 Binding Protein 1 in sarcomeric protein stoichiometry and generation of muscle diversity in Drosophila melanogaster 

        Kamble, Ketaki
        Drosophila muscles are an excellent model to study muscle development, diversity and function. Drosophila muscles consist of two major types –1. Indirect Flight Muscles (IFM), that are fibrillar; as opposed to other tubular ...
      • Effects of Steroid Hormones on Insulin Sensitivity and Lipogenesis: An Insight into the Involvement of the Wnt Signaling Pathway 

        Alex, Neethu Sara
        The shift in maternal energy metabolism characteristic of pregnancy is thought to be driven by various hormonal changes, especially of ovarian and placental steroids. In this context, the effect of estradiol (E2), progesterone ...
      • Elucidating mechanisms regulating GC-C signalling in colorectal cancer 

        Nandi, Somesh
        Colorectal cancer is the third most frequently diagnosed cancer and the second major cause of cancer death worldwide. Classical therapies for treating colorectal cancer are mostly nonspecific and, therefore, are associated ...
      • Establishment of a knock-in mouse model expressing a hypomorphic variant of receptor guanylyl cyclase C 

        Chaukimath, Pooja P
        Receptor guanylyl cyclase C (GC-C, gene GUCY2C) is expressed on the apical surface of the intestinal epithelial cells and gets activated by the endogenous ligands guanylin and uroguanylin. Heat-stable enterotoxin (ST) ...
      • Functional characterization of WD40-repeat protein, WDR8, in Zebrafish to gain insight into its role in Isolated Microspherophakia 

        Madhangi, M
        WD40-repeat (WDR) proteins are a family of proteins that are characterized by widespread occurrence, low level of sequence conservation, common structural conformation (β propeller structure) and functional diversity. ...
      • Identifying novel molecular players involved in patterning the dorsal longitudinal muscles of Drosophila melanogaster 

        Mukherjee, Amartya
        Pattern formation, a fundamental concept in developmental biology, describes how living systems organise complex structures from initially undifferentiated cells. This process, influenced by genetic information, underpins ...
      • Influence of Tgf-B on Mechanobiology of Human Breast Cancer Cells 

        Kulkarni, Ankur Hemant
        Breast cancers are characterized by extensive modifications to mechanical properties of the tissue via increased ECM production and vascularization. TGF-B is a multi-functional cytokine that is implicated in cancer invasion ...
      • Investigations on the invasiveness of chemo-resistant epithelial ovarian cancer 

        Goutham, Shyamili
        Epithelial ovarian cancer (EOC) is a debilitating gynecological malignancy wherein patients frequently develop resistance to the first-line chemotherapeutic drugs carboplatin and docetaxel, resulting in poor survival rates. ...
      • Mechanistic insights into the role of miR‐6741‐3p in oral squamous cell carcinoma pathogenesis 

        More, Dhanashree Anil
        Many functional studies and clinical analysis have linked miRNA dysregulation as a causative factor for tumor initiation and progression. Overexpression of oncogenic miRNAs and downregulation of tumor suppressor miRNAs are ...
      • Molecular insights into AMP-activated protein kinase (AMPK)-mediated regulation of anoikis resistance 

        Kumar, Saurav
        Our study identifies negative cross-talk between AMPK and two important cellular kinases, Akt and Erk. AMPK-mediated inhibition of these two kinases promotes survival of cancer cells in the matrix-deprived condition. ...
      • Neuroimmune Regulation in Caenorhabditis elegans: The Roles of the Amphid Sensory Neurons and Olfaction in Host Immune Responses 

        Venkatesh, Siddharth R
        The ability of hosts to rapidly sense invading pathogens and mount an appropriate response is paramount for host survival. Pathogens, pervasive in the natural world, present a perpetual threat to host organisms. Examining ...

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