Browsing Department of Developmental Biology & Genetics (DBG, earlier called MRDG) by thesis submitted date"2025"
Now showing items 1-6 of 6
-
Biomechanical and biochemical regulation by the extracellular matrix of breast cancer migration
Although under active investigation, alterations within the microenvironment that are causative to, and a consequence of, tumor progression are only beginning to be better appreciated through advances in imaging, experimental, ... -
Deciphering the function of sesaminol as an anti-obesity and anti-MAFLD molecule
Obesity and its associated metabolic diseases, including type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) or metabolic dysfunction-associated liver disease (MAFLD), pose significant global health challenges. ... -
Deciphering the role of miR-631 in the pathogenesis of oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) is a malignant neoplasm originating from the epithelial cells of the oral cavity. The Asian population has the highest incidence of OSCC and despite advances in its treatment, the five-year ... -
Elucidating the TSC2-mediated transcriptional regulation of miR-514b-3p
The PI3K-AKT-MTOR signalling axis is pivotal in regulating cell survival, proliferation, and growth. Tuberous sclerosis complex (TSC) is a well-established negative regulator of this pathway, which primarily acts by ... -
Mechanistic insights into the recruitment of viral type 2 IRES to ribosomal pre-initiation complex and its interaction with eIF4 factors and PTB1
Viruses often employ internal ribosome entry sites (IRESs) in their genomic RNA to hijack the host’s translational machinery. The IRES elements are characterized by unique secondary and tertiary RNA structures capable of ... -
Towards a molecular understanding of gastrointestinal disorders due to mutations in receptor Guanylyl Cyclase C
Towards a molecular understanding of gastrointestinal disorders due to mutations in receptor Guanylyl Cyclase C Receptor guanylyl cyclase C (GC-C) is a complex multidomain protein receptor characterised by its guanylyl ...