Browsing Molecular Reproduction, Development and Genetics (MRDG) by thesis submitted date"2018"
Now showing items 1-10 of 10
-
Biochemical and functional characterisation of cyclic AMP-binding, universal stress proteins from mycobacteria
The genus Mycobacterium harbours several pathogenic species, including M. tuberculosis, the causative agent of tuberculosis, which alone is responsible for nearly 1.3 million deaths globally every year. Understanding the ... -
Biochemical and functional characterization of the enigmatic MPPED1/MPPED2 metallophosphodiesterases
Evolutionarily conserved genes in nature have been known to perform critical functions inside the cell. Earlier bioinformatic analysis performed in our laboratory identified mammalian orthologs of Rv0805, a novel class III ... -
Biochemical and Functional Characterization of the Mycobacterial PdtaS-PdtaR Two Component System
Two-Component Systems (TCSs) are primarily prokaryotic modes of cell signaling involving a receptor sensor kinase (SK) that senses stimuli and a response regulator (RR) that effects a response, usually at the level of ... -
Dissecting the role of Ataxin 2 Binding Protein 1 in sarcomeric protein stoichiometry and generation of muscle diversity in Drosophila melanogaster
Drosophila muscles are an excellent model to study muscle development, diversity and function. Drosophila muscles consist of two major types –1. Indirect Flight Muscles (IFM), that are fibrillar; as opposed to other tubular ... -
Influence of Tgf-B on Mechanobiology of Human Breast Cancer Cells
Breast cancers are characterized by extensive modifications to mechanical properties of the tissue via increased ECM production and vascularization. TGF-B is a multi-functional cytokine that is implicated in cancer invasion ... -
Investigating the role of taxi gene in flight behavior of Drosophila melanogaster
Locomotion is essential for animals and it is regulated by crosstalk between neurons and muscles. Although defects in the crosstalk between neurons and muscles are implicated in many mobility related diseases in human, ... -
Investigations on the regulatory role of BglG on the expression of ridA and the pleiotropic effects of bglG deletion in E. coli
The bgl operon of E. coli encodes for the proteins involved in the uptake and catabolism of plant-derived aromatic beta-glucosides, normally associated with the soil environment. The silent state of the operon seen ... -
Molecular insights into AMP-activated protein kinase (AMPK)-mediated regulation of anoikis resistance
Our study identifies negative cross-talk between AMPK and two important cellular kinases, Akt and Erk. AMPK-mediated inhibition of these two kinases promotes survival of cancer cells in the matrix-deprived condition. ... -
Regulation of Notch signalling by hypoxia and AMPK in breast cancer
Developmental pathways such as Notch are known to regulate self-renewal and cell fate decisions in embryonic and adult tissue-specific stem cells, while deregulation of Notch signalling is associated with malignant ... -
Studies on differentiation of mouse GS-2 ES-cells to pancreatic β-islet-like cells and their functional maturation status
Embryonic stem cells (ES-cells) are an excellent source for generating insulin-producing β-islet cells for potential use in the management of diabetes mellitus. Although many protocols have been developed to promote the ...