Browsing Department of Developmental Biology & Genetics (DBG, earlier called MRDG) by Advisor "Hussain, Tanweer"
Now showing items 1-4 of 4
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Biochemical and structural studies to provide insights into initiator tRNA delivery by eIF2A in noncanonical translation initiation
Eukaryotic initiation factor 2A (eIF2A), a non-canonical translation initiation factor, delivers initiator tRNA (tRNAi) onto the 40S ribosomal subunit in a codon-dependent and GTP-independent manner, unlike the canonical ... -
Insights into mRNA recruitment by eukaryotic initiation factor 4 during translation in Saccharomyces cerevisiae
Ribosomes are responsible for synthesizing proteins in the cells by using mRNA as the template. However, the ribosomes cannot perform this function without the help of other protein factors. Different factors are required ... -
Mechanistic insights into the recruitment of viral type 2 IRES to ribosomal pre-initiation complex and its interaction with eIF4 factors and PTB1
Viruses often employ internal ribosome entry sites (IRESs) in their genomic RNA to hijack the host’s translational machinery. The IRES elements are characterized by unique secondary and tertiary RNA structures capable of ... -
Structural insight into unique features of the Translational apparatus in Plants
Plants are constantly challenged with a variety of biotic and abiotic stress conditions. Being sessile, plants cannot evade these conditions. Most of these sudden changes in environmental conditions require a quick change ...