| dc.description.abstract | Sensors play a crucial role in addressing the need for the detection of antibiotics as emerging
contaminants in water. The widespread use of pharmaceuticals/antibiotics in various sectors,
including healthcare and agriculture, has led to their increased presence in water sources, posing a
potential threat to both human health and the environment. Antibiotics in water can cause the
development of antibiotic-resistant bacteria, a significant public health concern.
Chemical/biosensors offer a rapid and sensitive means of detecting trace levels of antibiotics in
water, enabling early identification of contamination. This early detection is essential for
implementing timely mitigation strategies and preventing the further spread of antibiotic residues.
Moreover, chemical/biosensors provide a cost-effective solution compared to traditional
laboratory methods. Their ability to operate in real-time enhances the capability to assess the
dynamic nature of antibiotic contamination. As of the present date, a multitude of sensing systems
and methodologies have been devised. However, the widespread commercialization and large
scale deployment of these sensors are impeded by their constrained sensitivity, selectivity, and
environmental stability. The thesis, titled “Design and Development of Biomimetic Sensor
Technologies for the Identification of Emerging Contaminants" seeks to address some
pharmaceuticals that are emerging pollutants and metal ions in aqueous streams by proposing
solutions to enhance the sensor characteristics through chemical/biosensors. Through systematic
investigation and development, this research aims to contribute advancements that will facilitate
the practical application and broader implementation of sensing technologies in environmental
monitoring and the healthcare sector.
Within the framework of this thesis, there is an in-depth exploration of the design and development
of innovative sensing materials and analytical methods, with a particular focus on addressing
emerging contaminants/pharmaceuticals and metal ions. The research employs biomimicking
techniques to achieve the objectives. A systematic approach was adopted, commencing with the
identification of the analyte and extending to the thorough evaluation of sensor parameters.
Tetracyclines were selected as the primary analyte of interest due to their extensive usage against
gram-positive and gram-negative bacteria, ranking as the second most widely used antibiotics
globally, following penicillin. Dopamine emerged as a secondary analyte of interest, chosen for
its relevance, as its concentration significantly impacts individual health. Additionally, tryptophan, an essential amino acid, levothyroxine provided as a supplement for thyroid deficiency, sodium
ions indicative of hydration status through sweat analysis, and magnesium ions were chosen as
analytes for comprehensive investigation within the thesis. This selection reflects a deliberate and
diverse approach aimed at addressing various aspects relevant to environmental and human health. | en_US |
