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dc.contributor.advisorChakravarthy, Akhil R
dc.contributor.advisorDas, Debasis
dc.contributor.authorUpadhyay, Aarti
dc.date.accessioned2024-10-23T04:59:06Z
dc.date.available2024-10-23T04:59:06Z
dc.date.submitted2024
dc.identifier.urihttps://etd.iisc.ac.in/handle/2005/6654
dc.description.abstractThe present thesis portrays the rational design and successful synthesis of platinum(II) complexes for achieving photoactivated dual action anticancer properties. The research project centers on synthesis, comprehensive characterization including crystallization and mechanistic aspects of the photocytotoxic behavior. Basic theoretical investigations were carried out to get an overview of frontier orbitals and photophysical properties. Photobiological aspects of synthesized complexes such as interactions with DNA, photoactivated cleavage of double-stranded DNA, in vitro photo-induced ROS generation and cytotoxicity, mode of cell death and mechanism of action in inducing cell death were studied. Intracellular fate of red fluorescent complexes along with mechanistic investigations of cellular incorporation pathways were also investigated.en_US
dc.language.isoen_USen_US
dc.relation.ispartofseries;ET00664
dc.rightsI grant Indian Institute of Science the right to archive and to make available my thesis or dissertation in whole or in part in all forms of media, now hereafter known. I retain all proprietary rights, such as patent rights. I also retain the right to use in future works (such as articles or books) all or part of this thesis or dissertationen_US
dc.subjectPlatinum(II) complexesen_US
dc.subjectBODIPYen_US
dc.subjectCurcuminen_US
dc.subjectRed lighten_US
dc.subjectSinglet oxygenen_US
dc.subjectHydroxyl radicalen_US
dc.subjectMitochondriaen_US
dc.subjectEndoplasmic Reticulumen_US
dc.subjectPhotodynamic therapyen_US
dc.subjectCellular Imagingen_US
dc.subject.classificationResearch Subject Categories::NATURAL SCIENCES::Chemistry::Inorganic chemistryen_US
dc.titlePhotodynamic Therapy and Cellular Imaging using Platinum(II) Conjugates of Boron-dipyrromethene and Curcuminen_US
dc.typeThesisen_US
dc.degree.namePhDen_US
dc.degree.levelDoctoralen_US
dc.degree.grantorIndian Institute of Scienceen_US
dc.degree.disciplineFaculty of Scienceen_US


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