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dc.contributor.advisorChatterjee, Kaushik
dc.contributor.advisorSaini, Deepak K
dc.contributor.authorYadav, Parul
dc.date.accessioned2024-01-03T10:15:14Z
dc.date.available2024-01-03T10:15:14Z
dc.date.submitted2023
dc.identifier.urihttps://etd.iisc.ac.in/handle/2005/6360
dc.description.abstractAging is a ubiquitous process that results in the progressive and irreversible loss of function. It is induced by accumulating damage caused by a variety of stressors, both internal and external. Although the advancement of modern medicine has enhanced human health and significantly extended life expectancy, with the aging of society, various age-associated chronic diseases have gradually become the primary cause of disability and death. The world’s population of people aged 60 years and older is growing rapidly, meaning people worldwide live longer. Thus, a segment of the population considered an outlier and excluded from drug screening and disease-based studies has now become the primary focus of research. The aging process starts at the cellular level, and cellular senescence is a major contributing factor. Traditionally, cellular senescence has been studied using conventional two-dimensional (2D) cell culture systems, which do not recapitulate the complex three-dimensional (3D) microenvironment of the soft human tissues. On the other hand, animal models suffer from various limitations, such as high cost, ethical concerns, and physiological differences between species. These challenges underscore the need for engineering organotypic models to investigate senescence and screen anti-aging drugs. The work lays the groundwork for developing more complex 3D scaffolds to decipher the aging process by utilizing conventional fabrication methods such as electrospinning and salt leaching with modern state-of-the-art 3D printing. Furthermore, the fabricated model systems can be used as drug-testing platforms for senolytic and senostatic drugsen_US
dc.language.isoen_USen_US
dc.relation.ispartofseries;ET00372
dc.rightsI grant Indian Institute of Science the right to archive and to make available my thesis or dissertation in whole or in part in all forms of media, now hereafter known. I retain all proprietary rights, such as patent rights. I also retain the right to use in future works (such as articles or books) all or part of this thesis or dissertationen_US
dc.subjectAgingen_US
dc.subject3D scaffoldsen_US
dc.subject2D cell culture systemsen_US
dc.subjecthuman tissuesen_US
dc.subjectsenescenceen_US
dc.subjecttherapy-included senescenceen_US
dc.subjectlung cancer epithelial cellsen_US
dc.subject.classificationResearch Subject Categories::TECHNOLOGY::Bioengineeringen_US
dc.titleNew Dimension in Senescence: Unraveling Cellular Senescence in Three-Dimensional Scaffoldsen_US
dc.typeThesisen_US
dc.degree.namePhDen_US
dc.degree.levelDoctoralen_US
dc.degree.grantorIndian Institute of Scienceen_US
dc.degree.disciplineEngineeringen_US


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